What is this medication and its most common uses?Kazano is a medicine used along with diet and exercise to help control high blood sugar in adults with type 2 diabetes. Kazano contains two medicines that work in two different ways to lower your blood sugar levels: alogliptin and metformin.
What should I know when beginning and continuing on this medication?How does this medication work?
Alogliptin helps your body release more insulin. Metformin helps your body respond better to the insulin it makes naturally, decreasing the amount of sugar your liver makes, and decreasing the amount of sugar your intestines absorb. Together, they help to control your blood sugar.
What are the beneficial effects of this medication and when should I begin to have results?
What: Lowering your blood sugar to a normal level may prevent or delay potential complications associated with diabetes, such as blindness, kidney failure, or heart problems. Also, the combination of medicines in Kazano provides better control of blood sugar compared to either alogliptin or metformin alone.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Kazano exactly as your healthcare provider has prescribed.
How do I know it is working?
Check your blood sugar regularly and as your healthcare provider tells you to. Your healthcare provider will also do regular blood tests to measure your blood sugar levels and your hemoglobin A1C (measures your average blood sugar levels over a 2- to 3-month period). Stay on your prescribed diet and exercise program, as this will also affect the results of your blood tests.
What are the possible side effects of this medication?The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
Kazano can cause a life-threatening condition called lactic acidosis (a build-up of an acid in the blood). This is a medical emergency and must be treated in the hospital. Stop taking Kazano and call your healthcare provider right away if you feel very weak or tired; have unusual muscle pain, trouble breathing, sleepiness or you sleep longer than usual; develop sudden stomach or intestinal problems with nausea, vomiting, or diarrhea; feel cold, especially in your arms and legs; experience dizziness or lightheadedness; or have a slow or irregular heartbeat.
You have a higher chance of getting lactic acidosis if you have kidney or liver problems; have heart failure that requires treatment with medicines; drink a lot of alcohol; become dehydrated (lose a large amount of body fluids); have certain tests with dyes or contrast agents that are injected into your body; undergo surgery; or experience a heart attack, severe infection, or stroke.
More common side effects may include: upper respiratory infection, stuffy or runny nose and sore throat, diarrhea, increase in your blood pressure, headache, back pain, urinary tract infection.
Less common side effects may include:
Pancreatitis (inflammation of the pancreas) with symptoms such as pain in your abdomen (stomach area) that is severe and will not go away. You may feel the pain going from your abdomen through to your back and may experience vomiting.
Serious allergic reactions with symptoms such as rash; hives; and swelling of your face, lips, tongue, or throat that may cause trouble breathing.
Liver problems, with symptoms such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, and yellowing of your skin or the whites of your eyes.
Low blood sugar with symptoms such as shaking, sweating, rapid heartbeat, changes in your vision, hunger, headache, or changes in your mood. Your risk of low blood sugar is higher if you do not eat enough, drink alcohol, or take other medicines to lower your blood sugar.
Kazano may also lower vitamin B12 levels in your blood. Your healthcare provider may check your vitamin B12 blood levels periodically while you are taking Kazano.
Who should not take this medication?Do not take Kazano if you are allergic to it or any of its ingredients.
Do not take Kazano if you have kidney problems, or are going to receive an injection of dye or contrast agents for an x-ray procedure.
What should I tell my healthcare provider before I take the first dose of this medication?Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Kazano. Also, talk to your healthcare provider about your complete medical history, especially if you have pancreatitis; gallstones (stones in your gallbladder); heart, kidney, or liver problems; drink alcohol frequently; or if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous diabetes medication, and may adjust your dose as needed, until the desired effect is achieved.
If you are also using insulin or taking another diabetes medicine called a sulfonylurea (such as glimepiride, glipizide, or glyburide), your healthcare provider may adjust the dose of these medicines.
How should I take this medication?Take Kazano exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Kazano without first talking to your healthcare provider.
Take Kazano twice a day. Take it with food to lower your chance of having an upset stomach.
Swallow Kazano tablets whole. Do not break or cut the tablets.
If your body is under some types of stress (such as a fever, infection, trauma [such as a car accident], or surgery), your healthcare provider may need to adjust the dose of your diabetes medicine.
While you are taking Kazano, stay on your diet and exercise program, and check your blood sugar regularly as directed by your healthcare provider.
What should I avoid while taking this medication?Do not drink excessive amounts of alcohol while taking Kazano. Alcohol can increase your chance of developing lactic acidosis.
What are the possible food and drug interactions associated with this medication?If Kazano is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Kazano may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
May I receive this medication if I am pregnant or breastfeeding?The effects of Kazano during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of this medication?If you miss a dose of Kazano, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store this medication?Store at room temperature.