Ketorolac tromethamine

Generic Name: Ketorolac

  • What is this medication and its most common uses?

    Ketorolac tablets are in a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs) and are used for the short-term (up to 5 days) treatment of pain.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Ketorolac tablets relieve pain by blocking a substance in your body that is involved in causing inflammation and pain.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Ketorolac tablets have been shown to reduce pain.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take ketorolac tablets exactly as your healthcare provider has prescribed.

    How do I know it is working?

    You may feel a relief in your pain after you start taking ketorolac tablets. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Do not use ketorolac tablets for more than 5 days in a row. If you are still experiencing pain after 5 days, contact your healthcare provider.

    Do not use ketorolac tablets in children or for minor or long-term pain.

    Ketorolac tablets may increase the chance of a life-threatening heart attack or stroke. The risk of heart attack or stroke may be increased with longer use and in people who have heart disease. Call your healthcare provider right away if you develop chest pain, shortness of breath, weakness, or slurring of your speech while taking ketorolac tablets.

    Ketorolac tablets should never be used right before or after a heart surgery called a coronary artery bypass graft (CABG).

    Ketorolac tablets can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can be life-threatening and may happen without warning symptoms. The chance of a person getting an ulcer or bleeding increases with longer use, smoking, drinking alcohol, older age, having poor health, and if you are taking medicines called corticosteroids (such as prednisone) or blood thinners (such as warfarin). Call your healthcare provider right away if you develop stomach pain, indigestion, bloody or tarry stools, or you vomit blood while taking ketorolac tablets.

    Ketorolac tablets can also cause other bleeding problems. Tell your healthcare provider if you have any type of bleeding disorder before you start using ketorolac tablets.

    Ketorolac tablets can cause kidney problems. Tell your healthcare provider if you have any kidney problem before you start using ketorolac tablets.

    Ketorolac tablets should never be used before any major surgery or during labor and delivery.

    Ketorolac tablets should never be used with aspirin or other NSAIDs (such as ibuprofen or naproxen).

    If you are elderly, weigh <110 pounds, or have kidney problems, your healthcare provider may adjust your dose for you.

    More common side effects may include: stomach pain, upset stomach, nausea, headache.

    Less common side effects may include:

    Liver problems with symptoms such as nausea, tiredness, weakness, itching, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.

    Serious allergic reactions with symptoms such as skin rash, blisters, fever, itching, trouble breathing, or swelling of your face or throat.

    Ketorolac tablets may cause high blood pressure, anemia (low red blood cell counts), or unexplained weight gain or swelling.

  • Who should not take this medication?

    Do not take ketorolac tablets if you are allergic to them or any of their ingredients.

    Do not take ketorolac tablets if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID.

    Do not take ketorolac tablets for pain right before or after a heart bypass surgery.

    Do not take ketorolac tablets if you have or have had a history of an ulcer or bleeding in your stomach or intestines.

    Do not take ketorolac tablets before any major surgery or during labor and delivery.

    Do not take ketorolac tablets if you have kidney disease.

    Do not take ketorolac tablets if you have certain other bleeding problems.

    Do not take ketorolac tablets if you are currently taking aspirin, other NSAIDs, probenecid, or pentoxifylline.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with ketorolac tablets. Also talk to your healthcare provider about your complete medical history, especially if you have asthma; high blood pressure; heart failure; kidney or liver problems; a history of ulcers or bleeding in your stomach or intestines; other bleeding problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults and adolescents ≥17 years: The usual dose is 20 milligrams (mg) once, then 10 mg every 4 to 6 hours. Do not take more than 40 mg in one day.

    If you are elderly, have kidney problems, or weigh <110 pounds, your healthcare provider may recommend a lower dose.

  • How should I take this medication?

    Take ketorolac tablets exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

  • What should I avoid while taking this medication?

    Do not take ketorolac tablets for more than 5 days in a row. If you are still experiencing pain after 5 days, call your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If ketorolac tablets are taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining ketorolac tablets with the following: alprazolam, antidepressant medications known as selective serotonin reuptake inhibitors (SSRIs) (such as citalopram and sertraline), aspirin, blood thinners (such as warfarin), certain blood pressure/heart medications (such as lisinopril or valsartan), fluoxetine, lithium, methotrexate, pentoxifylline, probenecid, seizure medicines (such as phenytoin and carbamazepine), thiothixene, or water pills (such as furosemide or hydrochlorothiazide).

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take ketorolac tablets if you are in the late stage of your pregnancy. The effects of ketorolac tablets during early pregnancy are unknown. The chemicals in ketorolac tablets may be found in your breast milk if you take the tablets while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of ketorolac tablets, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

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