Generic Name: Anakinra

  • What is Kineret?

    Kineret is used to slow down the damage that happens to patients with moderate to severe active rheumatoid arthritis (RA) and reduce the signs and symptoms of RA. Kineret is only for adults who have taken other medicines for their RA that have not worked. Kineret can be taken alone, or with other RA medicines other than tumor necrosis factor (TNF)-blocking agents.

  • What is the most important information I should know about Kineret?

    Kineret is a medicine that affects your immune system. It can lower the ability of your immune system to fight infections. Serious infections have occurred in patients taking Kineret. During treatment with Kineret, call your doctor right away if you develop an infection, experience any sign of an infection (including fever, chills), or have any open sores on your body.

    You could also have an increased risk of getting a serious infection if you take Kineret with other medicines that affect the immune system, such as adalimumab, etanercept, or infliximab. It is recommended that you do not take these medications while taking Kineret.

    It may take up to 12 weeks to see an improvement in your RA symptoms. The time it takes to see improvement in symptoms varies from person to person.

    Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Kineret.

    Avoid vaccinations with live virus vaccines (such as measles, mumps, oral polio) while you are taking Kineret.

    Let your doctor know if you have an allergy to rubber or latex because the needle cover on the Kineret prefilled syringe contains latex.

  • Who should not take Kineret?

    Do not take Kineret if you are allergic to the medication or any of its ingredients. Also, do not take Kineret if you have an allergy to proteins made from bacterial cells (E. coli). Ask your doctor if you are not sure.

  • What should I tell my doctor before I take the first dose of Kineret?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Kineret. Also, talk to your doctor about your complete medical history, especially if you have an infection, a history of infections that keep coming back, or other conditions that can increase your risk of infections. Also, tell your doctor if you have an allergy to rubber or latex, have kidney problems, are scheduled to receive any vaccines, are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose of Kineret is 100 milligrams (mg) taken as an injection under the skin once daily.

    Kidney impairment or failure: If you have severe kidney impairment or end-stage kidney disease, your doctor may consider a dose of 100 mg administered every other day.

  • How should I take Kineret?

    Kineret is injected under the skin. Your doctor will instruct you on how to properly inject Kineret and the correct way to dispose of used syringes. Take Kineret exactly as your doctor tells you to. If you have a kidney problem, your doctor may need to change how often you take your injections. Inject Kineret at about the same time each day, on a schedule that works best for you.

  • What should I avoid while taking Kineret?

    Avoid contact with anything that increases your risk of getting an infection while you are taking Kineret. Avoid receiving live virus vaccinations (eg, measles, mumps, oral polio) while you are taking Kineret, as well as taking etanercept, adalimumab, or infliximab.

  • What are possible food and drug interactions associated with Kineret?

    If Kineret is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before being vaccinated with a live vaccine or before combining Kineret with other medicines that affect the immune system, such as the following TNF-blocking agents: adalimumab, etanercept, or infliximab.

  • What are the possible side effects of Kineret?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: injection site reactions (such as redness, swelling, bruising, itching), serious infections, neutropenia (white blood cells called neutrophils that are decreased in number), lymphoma (a type of cancer), allergic reactions

  • Can I receive Kineret if I am pregnant or breastfeeding?

    The effects of Kineret during pregnancy and breastfeeding are unknown. Kineret should only be used during pregnancy if clearly needed. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Kineret?

    If you miss a dose of Kineret, contact your doctor to find out when to take your next injection.

  • How should I store Kineret?

    Store Kineret in its original carton in the refrigerator. Do not freeze or shake it. Keep away from light. When you are traveling, make sure to store Kineret at the correct temperature. Do not save any unused portion of the medication, and do not use any expired medication.

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