Kombiglyze XR

Generic Name: Saxagliptin

  • What is Kombiglyze XR?

    Kombiglyze XR is a prescription medicine that contains saxagliptin and metformin. It is used with diet and exercise to help control high blood sugar in adults with type 2 diabetes.

  • What is the most important information I should know about Kombiglyze XR?

    Metformin, one of the medicines in Kombiglyze XR, can cause a rare, but serious side effect called lactic acidosis (a build-up of lactic acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital. Stop taking Kombiglyze XR and call your doctor right away if you get any of the following symptoms of lactic acidosis: feel very weak and tired, have unusual muscle pain, trouble breathing, unusual sleepiness or sleep longer than usual, unexplained stomach or intestinal problems with nausea, vomiting, or diarrhea, feel cold (especially in your arms and legs), feel dizzy or lightheaded, or have a slow or irregular heartbeat.

    When your body is under some types of stress, including fever, trauma (such as a car accident), infection, or surgery, the amount of diabetes medicine that you need may change. Tell your doctor right away if you have any of these problems or if you have problems with low blood sugar.

    Be sure to get all recommended tests before and during treatment with Kombiglyze XR (such as kidney function, blood sugar or hemoglobin A1C levels, and any other blood tests) and stay on your prescribed diet and exercise program. Follow instructions on how to check, recognize signs of, and treat low blood sugar.

  • Who should not take Kombiglyze XR?

    Do not take Kombiglyze XR if you have kidney problems, are allergic to metformin, saxagliptin, or any of the ingredients in Kombiglyze XR, have type 1 diabetes, are going to get an injection of dye or contrast agents for an x-ray procedure, or if you are going to have surgery and are not able to eat or drink much.

  • What should I tell my doctor before I take the first dose of Kombiglyze XR?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Kombiglyze XR. Also, talk to your doctor about your complete medical history, especially if you have type 1 diabetes, kidney or liver problems, heart problems, including congestive heart failure, are older than 80 years, drink a lot of alcohol, are taking insulin, have any other medical conditions, or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Your doctor will prescribe the appropriate dose based on your current treatment, and adjust your dose depending on how well you respond to Kombiglyze XR and tolerate side effects.

  • How should I take Kombiglyze XR?

    Take Kombiglyze XR exactly as your doctor tells you. Kombiglyze XR should be taken with meals to help avoid an upset stomach.

    Swallow Kombiglyze XR whole. Do not crush, cut, or chew the tablets.

  • What should I avoid while taking Kombiglyze XR?

    Avoid missing follow-up visits with your doctor during treatment with Kombiglyze XR for recommended or routine blood tests.

    Avoid heavy alcohol use and other activities that may worsen your condition or put you at risk for harmful side efffects.

  • What are possible food and drug interactions associated with Kombiglyze XR?

    If Kombiglyze XR is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Kombiglyze XR with the following: alcohol, amiloride, antibiotics (such as clarithromycin, telithromycin, vancomycin), antifungals (such as itraconazole, ketoconazole), blood pressure medicines in a class called calcium channel blockers, corticosteroids, digoxin, estrogens, HIV/AIDS medicines (such as atazanavir, indinavir, nefazodone, saquinavir), medicines that can cause low blood sugar (such as insulin), isoniazid, morphine, nicotinic acid, birth control pills, phenytoin, procainamide, quinidine, quinine, ranitidine, diuretics (water pills), thyroid products, triamterene, or trimethoprim.

  • What are the possible side effects of Kombiglyze XR?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: low blood sugar (symptoms include shaking, sweating, rapid heartbeat, change in vision, hunger, headache, change in mood), lung infections, stuffy or runny nose and sore throat, urinary tract infection, headache, diarrhea, nausea, vomiting

  • Can I receive Kombiglyze XR if I am pregnant or breastfeeding?

    The effects of Kombiglyze XR during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Kombiglyze XR?

    If you miss a dose of Kombiglyze XR, take your next dose as prescribed unless your doctor tells you differently. Do not take an extra dose the next day to make up for the missed dose.

  • How should I store Kombiglyze XR?

    Store at room temperature.

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