Krystexxa

Generic Name: Pegloticase

  • What is Krystexxa?

    Krystexxa is a medicine used to help reduce the signs and symptoms of gout that are not controlled by other treatments. Krystexxa works to lower uric acid levels in your blood. This medication is administered intravenously (through a vein in your arm).

  • What is the most important information I should know about Krystexxa?

    Krystexxa can cause anaphylaxis (a serious and rapid allergic reaction that may result in death if not immediately treated) or infusion reactions. These reactions can be life-threatening and usually happen within 2 hours of the infusion. Your doctor will administer Krystexxa in a healthcare setting where serious allergic reactions can be treated immediately. Your doctor may give you other medicines to help reduce your chance of getting a reaction. Tell your doctor immediately if you develop wheezing, difficulty breathing, chest discomfort or pain, swelling of your throat or tongue, rash, dizziness, fast or weak heartbeat, redness of your skin, or flushing.

    When you first start receiving Krystexxa, your gout may become worse (gout flares). Your doctor might prescribe other medications to help prevent this.

  • Who should not take Krystexxa?

    Your doctor will not administer Krystexxa to you if you are allergic to it, any of its ingredients, or if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency (lack of an enzyme responsible for the breakdown of red blood cells).

  • What should I tell my doctor before I take the first dose of Krystexxa?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Krystexxa. Also, talk to your doctor about your complete medical history, especially if you have G6PD deficiency, heart failure or other heart problems, high blood pressure, are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is 8 milligrams (mg) every two weeks.

  • How should I take Krystexxa?

    Your doctor will administer Krystexxa intravenously for you.

  • What should I avoid while taking Krystexxa?

    Do not miss your scheduled follow-up appointments with your doctor.

  • What are possible food and drug interactions associated with Krystexxa?

    No significant interactions have been reported with Krystexxa at this time. However, always tell your doctor about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

  • What are the possible side effects of Krystexxa?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: allergic reactions, bruising, chest pain, constipation, gout flares, sore throat, vomiting

  • Can I receive Krystexxa if I am pregnant or breastfeeding?

    The effects of Krystexxa during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Krystexxa?

    Krystexxa should be given under special circumstances determined by your doctor. If you miss your scheduled appointment, contact your doctor for advice.

  • How should I store Krystexxa?

    Your doctor will store this medication for you.