Generic Name: Baclofen

  • What is this medication and its most common uses?

    Lioresal is a medicine used to treat severe muscle spasms due to certain brain or spinal cord disorders. Lioresal is administered intrathecally (injected into your spinal fluid).

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Lioresal is thought to work by relaxing your muscles, thereby relieving symptoms of muscle spasms.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Lioresal has been shown to reduce the frequency of muscle spasms due to spinal cord or brain injury, multiple sclerosis, or cerebral palsy.

    When: After you have been given a test dose and your healthcare provider begins administering Lioresal to you continuously, you may experience less muscle spasms 6 to 8 hours after the infusion is started.

    How do I know it is working?

    You may start to notice an improvement in your symptoms. Your healthcare provider may also ask you questions from time to time to assess how well your spasms are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Do not stop receiving Lioresal without first talking to your healthcare provider. Stopping Lioresal suddenly may cause a high fever, changes in mental status, or worsened muscle spasms. Do not miss your scheduled refill visits with your healthcare provider. Call your healthcare provider right away if you experience itching, low blood pressure, tingling or numbness of your hands or feet, or your muscle spasms come back.

    Muscle Spasms Due to Spinal Cord Disorders

    More common side effects may include: drowsiness, dizziness, nausea, low blood pressure, headache, seizures, decreased muscle tone.

    Muscle Spasms Due to Brain Disorders

    More common side effects may include: agitation, constipation, drowsiness, increased white blood cell counts, chills, inability to urinate normally, decreased muscle tone.

    Less common side effects of Lioresal may include:

    Increased risk of ovarian cysts in women.

  • Who should not take this medication?

    Your healthcare provider will not administer Lioresal to you if you are allergic to it or any of its ingredients.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Lioresal. Also, talk to your healthcare provider about your complete medical history, especially if you have a mental illness (such as a mood disorder or schizophrenia), an infection, or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults and children ≥4 years: Your healthcare provider will prescribe the appropriate dose for you or your child.

  • How should I take this medication?

    Your healthcare provider will administer Lioresal to you.

  • What should I avoid while taking this medication?

    Do not miss your scheduled follow-up appointments with your healthcare provider.

    Do not drink alcohol or take other medicines that make you sleepy or dizzy while you are receiving Lioresal without first talking with your healthcare provider.

    Do not drive, operate heavy machinery, or do other dangerous activities until you know how Lioresal affects you.

  • What are the possible food and drug interactions associated with this medication?

    If Lioresal is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Lioresal with the following: alcohol or morphine.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of Lioresal during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    Lioresal should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

  • How should I store this medication?

    Your healthcare provider will store this medication for you.