Generic Name: Diphenoxylate

  • What is Lomotil?

    Lomotil is a combination product taken with other medications to treat diarrhea.

  • What is the most important information I should know about Lomotil?

    Follow Lomotil dosing instructions strictly. Taking too much may result in severe breathing problems and even death.

    When taking Lomotil, drink adequate fluids as directed by your doctor. Electrolytes (such as potassium and sodium) may be needed. If dehydration or electrolyte imbalance occurs, do not use Lomotil.

    Lomotil may cause toxic megacolon (widening of the large intestine) in patients with ulcerative colitis (inflammatory disease of the large intestines).

    Do not use Lomotil if the diarrhea is caused by bacteria or food poisoning.

  • Who should not take Lomotil?

    You should not take Lomotil if you are sensitive or allergic to its ingredients, have certain liver diseases, or have diarrhea due to bacteria.

  • What should I tell my doctor before I take the first dose of Lomotil?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Lomotil. Also, talk to your doctor about your complete medical history, especially if you have been diagnosed with a condition called ulcerative colitis, have liver and kidney disease, or are taking an antidepressant medication known as a monoamine oxidase inhibitor (MAOI).

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults and adolescents >12 years: The usual starting dose is two tablets four times a day, or 2 teaspoonfuls of liquid four times a day.

    Based on your body's response to Lomotil, your doctor may reduce your dose to two tablets daily or 2 teaspoonfuls daily.

    Children 2-12 years: Your doctor will prescribe the appropriate dose for your child. Children should only use Lomotil liquid.

  • How should I take Lomotil?

    Take Lomotil exactly as prescribed by your doctor. Space out the dosing times evenly throughout the day and take Lomotil at the same times every day.

    If using Lomotil liquid for a child, use the plastic dropper provided for measuring and giving doses.

  • What should I avoid while taking Lomotil?

    Until you know how Lomotil affects you, be careful doing activities that require alertness, such as driving a car or operating machinery. Also, avoid drinking alcohol while taking this drug.

  • What are possible food and drug interactions associated with Lomotil?

    If Lomotil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Lomotil with alcohol, barbiturates (medications such as phenobarbital), MAOIs, or tranquilizers.

  • What are the possible side effects of Lomotil?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: numbness of arms and legs, feelings of happiness or well-being, depression, overall sick feeling/fatigue, confusion, tiredness/drowsiness, dizziness, restlessness, headache, allergic reactions, toxic megacolon, intestinal blockage, inflammation of the pancreas, vomiting, nausea, loss of appetite, stomach discomfort, increase in body temperature, rapid heartbeat, urinary retention, flushing (redness of the skin), dryness of the skin and mouth.

  • Can I receive Lomotil if I am pregnant or breastfeeding?

    The effects of Lomotil during pregnancy are unknown. Lomotil may be excreted in breast milk and may affect your baby. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Lomotil?

    If you miss a dose of Lomotil, do not take two doses at once. Skip the dose you missed and return to your normal dosing schedule.

  • How should I store Lomotil?

    Store at room temperature.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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