Generic Name: Amlodipine

  • What is this medication and its most common uses?

    Lotrel is a medicine used to treat high blood pressure. Lotrel contains two medicines that work in two different ways to reduce your blood pressure: amlodipine and benazepril.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Lotrel works by blocking a chemical in your body that causes blood vessels to narrow. By blocking this chemical, Lotrel relaxes and widens your blood vessels, allowing your blood to flow through with less resistance. This helps to lower your blood pressure.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: By lowering your blood pressure, Lotrel may lower your risk of a stroke or a heart attack.

    When: Lotrel may start lowering your blood pressure within 2 weeks. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: dizziness; fainting on standing up; cough; swelling of your feet, ankles, or hands.

    Less common side effects may include:

    Serious allergic reactions with symptoms such as swelling of your face, eyelids, lips, tongue, or throat; difficulty swallowing; asthma (wheezing) or other breathing problems; or abdominal (stomach area) pain. You may have an increased risk of experiencing these symptoms if you are African American.

    Low blood pressure with symptoms such as dizziness or fainting. Low blood pressure is most likely to happen if you also take water pills, are on a low-salt diet, get dialysis treatment, have heart problems, or get sick with vomiting or diarrhea.

    Possible increased chest pain or risk of a heart attack.

    Liver problems with symptoms such as nausea, feeling more tired or weaker than usual, itching, yellow skin or eyes, pain in your upper right stomach area, or flu-like symptoms.

    Kidney problems with symptoms such as swelling of your feet, ankles, or hands; or unexplained weight gain.

  • Who should not take this medication?

    Do not take Lotrel if you are allergic to it, any of its ingredients, or if you have a history of angioedema (a condition involving swelling of the face, extremities, eyes, lips, and tongue).

    Do not take Lotrel if you have diabetes and are taking another blood pressure medicine called aliskiren.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Lotrel. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes, a heart condition, liver or kidney problems, a history of angioedema, are about to have an operation or emergency treatment, suffering from several episodes of vomiting or diarrhea, being treated for high blood potassium levels, are taking a water pill, or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The recommended starting dose is 2.5/10 (2.5 milligrams [mg] of amlodipine and 10 mg of benazepril) once a day.

    If you have kidney or liver impairment, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take Lotrel exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Lotrel without first talking to your healthcare provider.

    Take Lotrel at the same time each day, with or without food.

  • What should I avoid while taking this medication?

    Do not become pregnant while taking this medication.

    Do not drink alcohol until you have discussed the matter with your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If Lotrel is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Lotrel with the following: blood pressure/heart medicines, clarithromycin, diabetes medications (such as insulin), indinavir, injectable gold (sodium aurothiomalate), itraconazole, ketoconazole, lithium, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or indomethacin), potassium supplements, ritonavir, salt substitutes containing potassium, simvastatin, or water pills (such as amiloride, spironolactone, or triamterene).

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take Lotrel if you are pregnant or breastfeeding. Lotrel can harm your unborn baby. Lotrel can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Lotrel, take it as soon as you remember. However, if it is more than 12 hours, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from moisture.

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