What is Lupron Depot?This form of Lupron Depot decreases the amount of estrogen produced by the ovaries. It is used to treat the symptoms of endometriosis. It can also be given with norethindrone acetate for the initial management of endometriosis and for the recurrence of symptoms. Lupron Depot is also used with iron therapy to treat tissue overgrowth (fibroids) in the uterus when patients do not respond to iron therapy alone.
What is the most important information I should know about Lupron Depot?You should make sure you are not pregnant before starting Lupron Depot therapy. If you miss a dose, breakthrough bleeding or ovulation could occur, with the possibility of conception. If you become pregnant during treatment, stop taking Lupron Depot and contact your doctor immediately. You should not use it if you are breastfeeding or have undiagnosed vaginal bleeding. While taking Lupron Depot, you should use another form of nonhormonal birth control such as condoms, diaphragm with contraceptive cream/gel, or an intrauterine device.
Although very rare, some patients have experienced anaphylactic and asthma-related reactions after using Lupron Depot. Immediately stop using Lupron Depot if you notice any changes in your vision (such as seeing double or blurry vision) or you experience migraine headaches. Since you should stop getting your period with continued use of Lupron Depot, if you do still menstruate, inform your doctor.
When taking Lupron Depot, you may develop or have worsening of depression or experience memory disorders. Patients with a history of depression should be carefully monitored throughout treatment.
Taking Lupron Depot may decrease the density of your bones, so you should get regular bone-density exams and take a calcium supplement, especially if you are at risk for developing osteoporosis. Concurrent therapy with norethindrone acetate has been shown to be effective in reducing the loss of bone mineral density.
Use caution when taking Lupron Depot if you have high cholesterol or you currently smoke. Lupron Depot may cause water retention, which can worsen or complicate conditions such as epilepsy, migraines, heart or kidney dysfunction, or asthma.
During the first few weeks of treatment your symptoms may temporarily worsen, but they should subside as you continue therapy.
Who should not take Lupron Depot?Do not take Lupron Depot if you have undiagnosed vaginal bleeding, are pregnant, may be pregnant, or are breastfeeding. Also avoid this medication if you have experienced an allergic reaction to other drugs like Lupron Depot. You should not use co-treatment with norethindrone acetate if you have liver problems, known or suspected breast cancer, diseases of the blood vessels (thrombophlebitis or thromboembolism), or a brain condition called cerebral apoplexy.
What should I tell my doctor before I take the first dose of Lupron Depot?Mention all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Lupron Depot. Also, talk to your doctor about your complete medical history, especially if you have a history of vaginal bleeding, or you have an increased risk of developing osteoporosis (due to family history, certain medications, or chronic alcohol or tobacco use). You should tell your doctor immediately if you are pregnant or plan to become pregnant, or if you are breastfeeding. You should also inform your doctor if you have a history of depression, liver problems, blood clots, breast cancer, or cerebral apoplexy.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The usual dosage of Lupron Depot is 3.75 milligrams (mg) given once a month (approximately every 28-33 days) as an intramuscular injection, for up to 3 months. The recommended initial treatment is no more than 6 injections for endometriosis and up to 3 injections for uterine fibroids. If you need retreatment for endometriosis, therapy should be limited to 6 months.
The usual dosage of Lupron Depot 11.25 mg is given once every 3 months as an intramuscular injection. The recommended initial treatment with Lupron Depot 11.25 mg is no more than 2 injections for endometriosis and one injection for uterine fibroids. If you need retreatment for endometriosis, therapy should be limited to 6 months.
How should I take Lupron Depot?Lupron Depot should be administered under the supervision of your doctor. To help you remember when to receive each dose, mark your calendar to keep track of your office visits. It is important to receive this medication regularly to get the most benefit from it.
What should I avoid while taking Lupron Depot?Do not become pregnant or breastfeed while taking this drug.
What are possible food and drug interactions associated with Lupron Depot?There are no known drug or food interactions with Lupron Depot.
What are the possible side effects of Lupron Depot?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: hot flashes/sweating, headaches, emotional instability, decreased libido, acne, myalgia (muscular pain), reduction in breast size, joint disorders, general pain, nervousness, dizziness, depression, neuromuscular disorders or weakness, breast tenderness or pain, weight loss or gain, fluid retention, skin reactions, nausea and vomiting, vaginal dryness
Can I receive Lupron Depot if I am pregnant or breastfeeding?Lupron Depot may cause serious harm to an unborn baby if taken during pregnancy. Tell your doctor immediately if you are pregnant or plan to become pregnant. Because it is not known whether Lupron Depot is excreted in breast milk, do not use this drug if you are breastfeeding.
What should I do if I miss a dose of Lupron Depot?If you miss a dose of Lupron Depot, make another appointment as soon as possible to establish a new schedule. It is important not to miss any doses.
How should I store Lupron Depot?Store at room temperature.