Generic Name: Hydroxyprogesterone

  • What is Makena?

    Makena is a hormone medicine used in women who are pregnant and who have delivered a baby too early (preterm) in the past. Makena helps lower the risk of having a preterm baby again.

  • What is the most important information I should know about Makena?

    Do not miss a dose of Makena, and continue to receive the medicine once a week.

    Makena is not for pregnant women with more than one baby or with other risk factors for preterm birth.

  • Who should not take Makena?

    Do not use Makena if you are allergic to it, any of its ingredients, or castor oil.

    Do not use Makena if you have a history of blood clots or other blood clotting problems, breast cancer or other hormone-sensitive cancers, unusual vaginal bleeding not related to your current pregnancy, yellowing of the skin or whites of your eyes due to liver problems, liver tumors, or uncontrolled high blood pressure.

  • What should I tell my doctor before I take the first dose of Makena?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Makena. Also, talk to your doctor about your complete medical history, especially if you have diabetes or prediabetes, seizures, migraine headaches, asthma, heart problems, kidney problems, depression, or high blood pressure.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose is 250 milligrams (mg) or 1 milliliter (mL) administered once a week (every 7 days).

  • How should I take Makena?

    Your doctor will inject Makena into your hip area (upper outer area of the buttocks). You will start receiving Makena injections anytime between 16 weeks, 0 days of your pregnancy and 20 weeks, 6 days of your pregnancy. Makena will be injected once a week until week 37 of your pregnancy or when your baby is delivered, whichever happens first.

  • What should I avoid while taking Makena?

    Do not give yourself Makena injections.

  • What are possible food and drug interactions associated with Makena?

    No significant interactions have been reported with Makena at this time. However, always tell your doctor about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

  • What are the possible side effects of Makena?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: blood clots, depression, diarrhea, hives, itching, leg pain and swelling, nausea, reaction at the injection site, yellowing of skin and the whites of your eyes

  • Can I receive Makena if I am pregnant or breastfeeding?

    Makena is used during pregnancy. Makena does not cause harm to your baby during pregnancy or breastfeeding.

  • What should I do if I miss a dose of Makena?

    If you miss your scheduled dose, contact your doctor for advice.

  • How should I store Makena?

    Store at room temperature. Keep Makena in the original box upright. Makena should be used within 5 weeks after the first use.