Marplan

Generic Name: Isocarboxazid

  • What is Marplan?

    Marplan is an antidepressant medicine known as a monoamine oxidase inhibitor (MAOI). It is used to treat depression in people who have not responded well to other antidepressant medicines.

  • What is the most important information I should know about Marplan?

    Marplan can increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults. Your doctor will monitor you closely for clinical worsening, suicidality, or unusual behavior after you start taking antidepressants or a new dose. Tell your doctor immediately if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, or thoughts about suicide or dying; or if you have new symptoms or seem to be feeling worse.

    Marplan is not used to treat bipolar depression. You can experience manic episodes while you are taking Marplan, especially if you are at risk for bipolar disorder. Tell your doctor if you or a family member has a history of bipolar disorder, depression, or suicide.

    Marplan can cause a sudden increase in your blood pressure. Tell your doctor immediately if you experience headache, especially in the back of your head or neck, irregular heartbeat, neck stiffness or soreness, nausea, vomiting, sweating, fever, cold skin, sensitivity to light, or chest tightness. Do not eat cheese or other foods with a high tyramine content (such as sour cream or wine).

    Marplan can also cause low blood pressure, faintness, or drowsiness, which can impair your performance of certain hazardous tasks. Do not drive or operate machinery until you know how Marplan affects you. Also, do not drink alcohol while you are taking Marplan.

    Do not stop taking Marplan without first talking to your doctor. Stopping Marplan suddenly can cause other symptoms.

  • Who should not take Marplan?

    Do not take Marplan if you are allergic to it or any of its ingredients, or if you have a brain disorder, heart disease, high blood pressure, liver or kidney impairment, a history of headaches, or pheochromocytoma (tumor of the adrenal gland).

    Also, do not take Marplan in combination with another MAOI, dibenzazepine-related medications used to treat depression (such as amitriptyline or doxepin), bupropion, fluoxetine, buspirone, amphetamines, meperidine, dextromethorphan, foods with a high tyramine content (such as cheese), anesthetics, certain blood pressure medications or diuretics (water pills), excessive caffeine, or other medications that slow down your brain function (such as alcohol, phenobarbital, or narcotic painkillers).

  • What should I tell my doctor before I take the first dose of Marplan?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Marplan. Also, talk to your doctor about your complete medical history, especially if have a brain disorder, heart disease, high blood pressure, liver or kidney impairment, a history of headaches, pheochromocytoma, diabetes, depression, psychotic disorders (including bipolar disorder), hyperthyroidism (an overactive thyroid gland), or are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults and adolescents ≥16 years: The recommended starting dose is 10 milligrams (mg) twice a day. Your doctor may increase your dose as needed, until the desired effect is achieved.

  • How should I take Marplan?

    Take Marplan exactly as prescribed by your doctor. Do not stop taking this medication abruptly without first talking to your doctor.

  • What should I avoid while taking Marplan?

    Do not drive or operate machinery until you know how Marplan affects you.

    Do not drink alcohol while you are taking Marplan.

  • What are possible food and drug interactions associated with Marplan?

    If Marplan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Marplan with the following: antidiabetic medications, caffeine, certain blood pressure medications, disulfiram, foods with a high tyramine content, insulin, or other certain antidepressants or antipsychotics.

  • What are the possible side effects of Marplan?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: anxiety, chills, constipation, diarrhea, drowsiness, dry mouth, fainting, forgetfulness, headache, heavy feeling, impotence, irregular heartbeat, low blood pressure, nausea, numbness or tingling feeling, overly active, shakiness, sleep disturbance, sweating, tiredness, tremor, urinary frequency or hesitancy

  • Can I receive Marplan if I am pregnant or breastfeeding?

    The effects of Marplan during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Marplan?

    If you miss a dose of Marplan, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Marplan?

    Store at room temperature.