Mavik
Generic Name: Trandolapril
What is Mavik?
Mavik is used alone or with other medications to treat high blood pressure. In addition, Mavik is used to improve survival in certain people who have suffered heart attacks and have heart failure.What is the most important information I should know about Mavik?
Mavik can cause a rare but serious allergic reaction leading to extreme swelling of the face, lips, tongue, throat, or gut (causing severe abdominal pain). If you experience any of these symptoms, seek emergency medical attention right away.Mavik may rarely cause a yellowing of the skin or eyes, which can be a sign of liver dysfunction. Notify your doctor immediately if this occurs.
Mavik may cause lightheadedness or fainting caused by very low blood pressure, especially upon standing from a lying or sitting position. A very low blood pressure can also be caused by not drinking enough fluids, if you sweat too much, or have excessive diarrhea or vomiting. Mavik should be taken with caution in patients who have congestive heart failure.
You should not take any potassium supplements or salt substitutes without talking to your doctor first because Mavik could cause an increase in potassium levels in your blood (hyperkalemia). You are at risk of developing hyperkalemia if you have diabetes or kidney problems, or are taking potassium-sparing diuretics or anything with potassium in it.
If you get any type of infection (sore throat/fever) while taking Mavik, promptly report it to your doctor. Mavik may decrease your levels of infection-fighting white blood cells.
When taken during pregnancy, angiotensin-converting enzyme (ACE) inhibitors such as Mavik can cause injury and even death to the developing baby. If you are pregnant or plan on becoming pregnant, stop taking Mavik and contact your doctor immediately.
Who should not take Mavik?
You should not take Mavik if you have had a previous allergic reaction to it or are sensitive to it or any other ACE inhibitor.What should I tell my doctor before I take the first dose of Mavik?
Mention all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Mavik. Also, talk to your doctor about your complete medical history, especially if you are pregnant or plan on becoming pregnant, or if you have ever had an allergy or sensitivity to an ACE inhibitor such as Mavik. Also, inform your doctor if you have diabetes; liver, kidney, or heart disease; or bone marrow problems.What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.Hypertension
Adults: The usual starting dose is 1 milligram (mg) once a day in nonblack patients and patients not taking a diuretic. The usual starting dose in black patients is 2 mg once daily. Your doctor may increase your individual dose to 2-4 mg daily. Dose adjustments should be made at intervals of at least 1 week.
Patients treated with 4-mg, once-daily dosing may be treated with twice-daily dosing if they are not adequately responding. If their blood pressure is not controlled with just Mavik, another medicine known as a diuretic may be added.
If you are already taking a diuretic, stop taking it, if possible, 2-3 days before starting Mavik. This reduces the possibility of fainting or lightheadedness. If the diuretic cannot be discontinued, the starting dosage of Mavik should be 0.5 mg. If Mavik alone does not control your blood pressure, your doctor will have you start taking a diuretic again.
Heart Failure or Left-Ventricular Dysfunction
Adults: For heart failure after myocardial infarction (MI) or left-ventricular dysfunction after MI, the usual starting dose is 1 mg once daily. Your doctor may increase your individual dose up to 4 mg daily.
Renal Impairment (CrCl <30 mL/min) or Hepatic Cirrhosis
Adults: The usual starting dose is 0.5 mg daily. Your doctor may or may not increase your dose based on your individual condition.
How should I take Mavik?
Mavik can be taken with or without food and should be taken at the same time every day.What should I avoid while taking Mavik?
Avoid operating automobiles or heavy machinery until you know how Mavik will affect you. Avoid becoming very dehydrated and drink adequate fluids while taking Mavik, because this could cause your blood pressure to drop too low. Avoid taking potassium supplements or salt substitutes without talking to your doctor first.What are possible food and drug interactions associated with Mavik?
If Mavik is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Mavik with the following: certain inhalation anesthetics; potassium supplements; salt substitutes containing potassium; thiazide-type diuretics such as hydrochlorothiazide; "potassium sparing" diuretics such as spironolactone, amiloride, and triamterene; lithium; or nonsteroidal anti-inflammatory drugs (NSAIDs).What are the possible side effects of Mavik?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.Side effects may include: headache, dizziness, diarrhea, cough, low blood pressure, fainting, acid reflux, increased potassium blood levels, slow heart rate, low blood calcium levels, muscle weakness, inflammation of the stomach, intermittent pain and/or weakness, stroke
Can I receive Mavik if I am pregnant or breastfeeding?
Taking Mavik while you are pregnant could cause serious harm or even death to your unborn baby. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding. Mavik is excreted in breast milk, and should not be taken if you are breastfeeding.What should I do if I miss a dose of Mavik?
If you forget to take Mavik, do not take two doses at once. Skip the dose you missed and then return to your normal dosing schedule.How should I store Mavik?
Store at room temperature in a tightly closed container, and protect from light.
I'm Beth Isaac, PharmD. Welcome to PDR Health!
