Generic Name: Meclofenamate

  • What is this medication and its most common uses?

    Meclofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, rheumatoid arthritis, and osteoarthritis. Meclofenamate is also used to treat primary dysmenorrhea (pain associated with menstruation) and heavy blood loss during menstruation.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Meclofenamate blocks a substance in your body that is involved in causing inflammation and pain in parts of the body where there is pain and arthritis.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Meclofenamate has been shown to improve pain and symptoms of arthritis such as swelling, tenderness, and stiffness. Meclofenamate has also been shown to reduce menstrual flow and improve symptoms associated with menstruation.


    Pain: Meclofenamate has been shown to start reducing your pain within one hour of taking a dose.

    Rheumatoid Arthritis and Osteoarthritis: Meclofenamate may start to relieve your symptoms within a few days of taking a dose.

    How do I know it is working?

    You may feel a relief in your pain and arthritis symptoms after you start taking meclofenamate. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: diarrhea, nausea, vomiting.

    Less common side effects may include:

    Increased risk of bleeding and ulcers in your stomach or intestines, with symptoms such as stomach pain or bloody vomit or stools.

    Liver problems with symptoms such as nausea, tiredness, weakness, itching, yellowing of your skin or the whites of your eyes, right upper stomach pain, and flu-like symptoms.

    Meclofenamate may cause anemia (low red blood cell counts), kidney or eye problems, or spotting or bleeding between menstrual cycles. Tell your healthcare provider if you experience spotting or worsening of your menstrual blood flow.

  • Who should not take this medication?

    Do not take meclofenamate if you are allergic to it or any of its ingredients.

    Do not take meclofenamate if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID (such as ibuprofen or naproxen).

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with meclofenamate. Also, talk to your healthcare provider about your complete medical history, especially if you have asthma; high blood pressure or heart failure; kidney or liver problems; a history of ulcers or bleeding in your stomach or intestines; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.


    Adults and adolescents ≥14 years: The recommended dose is 50 milligrams (mg) every 4 to 6 hours. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

    Rheumatoid Arthritis and Osteoarthritis

    Adults and adolescents ≥14 years: The usual dose is 200 to 400 mg a day, divided into 3 or 4 equal doses as determined by your healthcare provider. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

    Menstrual Pain and Heavy Menstrual Blood Loss

    Adults and adolescents ≥14 years: The recommended dose is 100 mg three times a day, for up to six days, starting at the onset of menstrual bleeding.

    If you are elderly, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take meclofenamate exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

    Take meclofenamate with food or milk if you experience an upset stomach.

  • What should I avoid while taking this medication?

    Do not take other NSAIDs in combination with meclofenamate without first talking to your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If meclofenamate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining meclofenamate with the following: aspirin or warfarin.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of meclofenamate during pregnancy are unknown. Meclofenamate may be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking meclofenamate. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of meclofenamate, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from light and moisture.