Generic Name: Glipizide and metformin hydrochloride

  • What is Metaglip?

    Metaglip helps lower blood sugar in people with type 2 diabetes if diet, exercise, or other medications have not. Metaglip contains two different medications that work together to lower blood sugar in part by helping the body use insulin more effectively and prevent it from making too much sugar.
  • What is the most important information I should know about Metaglip?

    A small number of patients who have taken Metaglip have developed a rare but serious side effect known as lactic acidosis. Your chances of developing lactic acidosis increase if you do not have properly functioning kidneys, have kidney disease, heart disease, or liver impairment. Signs and symptoms of lactic acidosis include muscle weakness and pain, difficulty breathing, flulike symptoms, and abdominal pain.

    You should not take Metaglip if you have kidney or liver disease, acute or chronic metabolic acidosis, or chronic heart failure. Metaglip can cause your blood sugar to decrease, especially if taken with certain medications or if you have liver, kidney, or heart disease. The signs and symptoms of low blood sugar include lightheadedness, dizziness, shakiness, and hunger.

    You should not drink excessively for short or long periods of time while taking Metaglip. Once you have taken Metaglip consistently and have gotten used to its effects, you should inform your doctor immediately if you develop any sudden abdominal pain.

  • Who should not take Metaglip?

    You should not take Metaglip if you have kidney dysfunction or disease, congestive heart failure requiring medication, a known sensitivity or allergy to glipizide or metformin, or acute and chronic metabolic acidosis including diabetic ketoacidosis.
  • What should I tell my doctor before I take the first dose of Metaglip?

    You should tell your doctor that you are taking Metaglip before undergoing any imaging procedure such as an MRI or are scheduled for surgery.

    Mention all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Metaglip. Also, talk to your doctor about your complete medical history, especially if you drink alcohol excessively, are dehydrated, have liver or kidney problems, are taking medications like furosemide or digoxin for chronic heart failure, or are over 80 and have not had your kidney function checked.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    The dosage of Metaglip must be individualized on the basis of both effectiveness and tolerance while not exceeding the maximum recommended daily dose of 20 mg glipizide/2,000 mg metformin.

    Adults: The usual starting dose is 2.5/250 milligrams (mg) taken once daily with a meal. Depending on your individual fasting blood glucose level, your doctor may increase your dose to 2.5/500 mg taken twice daily, or up to a maximum daily dose of 10/2,000 mg.

  • How should I take Metaglip?

    Metaglip should be taken at the same time every day with food.
  • What should I avoid while taking Metaglip?

    You should avoid drinking alcohol excessively, becoming dehydrated, and allowing your blood sugar to drop by not eating at regular intervals throughout the day.
  • What are possible food and drug interactions associated with Metaglip?

    If Metaglip is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Metaglip with the following: amiloride, antibiotics (sulfonamide-type), antifungal medications, beta blockers, calcium channel blockers (such as nifedipine), chloramphenicol, corticosteroids, coumadin, digoxin, estrogens, phenothiazines (types of antipsychotics), isoniazid, nicotinic acid, oral contraceptives, phenytoin, probenecid, monoamine oxidase inhibitors, morphine, nonsteroidal anti-inflammatory medications (such as acetaminophen), procainamide, quinidine, quinine, ranitidine, sympathomimetic medications, thiazide-type diuretics (as well as other diuretics such as furosemide), thyroid medications, triamterene, trimethoprim, or vancomycin.
  • What are the possible side effects of Metaglip?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: diarrhea, nausea, upset stomach, low blood sugar

  • Can I receive Metaglip if I am pregnant or breastfeeding?

    You should not take Metaglip during pregnancy without first consulting your doctor. It is not known whether Metaglip is excreted in breast milk. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Metaglip?

    If you forget to take a dose of Metaglip, do not double your next dose. Skip the dose you missed and return to your normal dosing schedule.
  • How should I store Metaglip?

    Store at room temperature.