Methergine

Generic Name: Methylergonovine

  • What is Methergine?

    Methergine is a medication known as an ergot alkaloid that is used to help prevent and control bleeding in women after delivery of a baby. Methergine can also be used for other conditions, as determined by your doctor.

  • What is the most important information I should know about Methergine?

    Methergine should be given cautiously to those with sepsis (infection of the blood), obliterative vascular disease (disease of the blood vessels), and liver or kidney disease.

    Methergine oral tablets should not be taken for more than 1 week following childbirth.

  • Who should not take Methergine?

    You should not take Methergine if you have high blood pressure, are pregnant, are allergic to Methergine or any of its ingredients, or have had toxemia (a condition in pregnancy characterized by high blood pressure, leakage of protein in the urine, and swelling of the hands, feet, and face).

  • What should I tell my doctor before I take the first dose of Methergine?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Methergine. Also, talk to your doctor about your complete medical history, especially if you are pregnant or nursing, have high blood pressure, kidney disease, liver disease, or infection of the blood.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Methergine may be given as an injection or may be taken orally. If given as an injection, your doctor will prescribe and administer the appropriate dosage for you.

    Adults: For the oral tablet, the recommended dose is 1 tablet (0.2 milligrams) by mouth 3-4 times a day after childbirth for up to a maximum of 1 week.

  • How should I take Methergine?

    Methergine oral tablets should be taken by mouth 3-4 times a day, or as directed by your doctor.

  • What should I avoid while taking Methergine?

    Grapefruit and grapefruit juice may interact with Methergine. Discuss the use of grapefruit products with your doctor.

  • What are possible food and drug interactions associated with Methergine?

    If Methergine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Methergine with the following: azole antifungals (e.g. itraconazole, ketoconazole, voriconazole), ergot alkaloids (e.g. dihydroergotamine, ergotamine), fluconazole, fluoxetine, grapefruit juice, HIV protease or reverse transcriptase inhibitors (e.g. delavirdine, indinavir, nelfinavir), macrolide antibiotics (e.g. erythromycin, clarithromycin, troleandomycin), nefazodone, and saquinavir.

    This listing does not include all of the possible drug interactions that may occur. Always check with your doctor before combining Methergine with any other drugs, herbs, or supplements.

  • What are the possible side effects of Methergine?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: high blood pressure with or without headache and/or seizures, low blood pressure, nausea, vomiting

  • Can I receive Methergine if I am pregnant or breastfeeding?

    Methergine should not be used if you are pregnant. Talk with your doctor if you are nursing, pregnant, or plan on becoming pregnant.

  • What should I do if I miss a dose of Methergine?

    If you miss a dose of Methergine, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Methergine?

    Store Methergine tablets at room temperature.

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I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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