What is Metoprolol/HCTZ?Metoprolol/hydrochlorothiazide (HCTZ) is a combination medicine used to treat high blood pressure. Metoprolol/HCTZ contains two medicines: metoprolol tartrate, a medication in a class called beta-blockers, and hydrochlorothiazide, a diuretic (water pill).
What is the most important information I should know about Metoprolol/HCTZ?Take metoprolol/HCTZ regularly and continuously for it to be effective. Do not stop taking metoprolol/HCTZ suddenly without talking to your doctor. Abruptly stopping this medication can cause harmful effects. Your doctor should gradually reduce your dose to stop this medication.
Metoprolol/HCTZ can worsen heart failure, can cause asthmatic attacks or breathing problems, or can hide symptoms of low blood sugar levels if you have diabetes. Your doctor will monitor your heart, breathing, and blood sugar levels. Be sure to monitor your blood sugar levels on a regular basis.
Changes in body electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) and body fluids can occur with metoprolol/HCTZ. Tell your doctor if you develop dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, dizziness or fainting, low or no urine output, fast heartbeat, or nausea and vomiting.
Metoprolol/HCTZ can cause low blood potassium levels, which can affect your heart and cause irregular heartbeat. Take potassium supplements or increase your intake of potassium-rich foods. Also, the risk for low blood sodium levels can increase in hot weather. Tell your doctor if you will be exposed to high temperatures.
Who should not take Metoprolol/HCTZ?Do not take metoprolol/HCTZ if you are allergic to it, any of its ingredients, or sulfonamide medications (such as sulfamethoxazole). In addition, do not take metoprolol/HCTZ if you have a slow heart rate, heart failure, heart block, severe blood circulation disorders, or low or no urine output.
What should I tell my doctor before I take the first dose of Metoprolol/HCTZ?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with metoprolol/HCTZ. Also, talk to your doctor about your complete medical history, especially if you have allergies, heart problems or heart failure, a history of heart attack, lung problems (such as asthma), diabetes, liver or kidney impairment, lupus (disease that affects the immune system), thyroid problems, or are planning to have a major surgery.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Your doctor will prescribe the appropriate dose for you based on your previous blood pressure medication and will increase your dose as needed, until the desired effect is achieved.
How should I take Metoprolol/HCTZ?Take metoprolol/HCTZ exactly as prescribed by your doctor. You can take metoprolol/HCTZ with or immediately following meals.
What should I avoid while taking Metoprolol/HCTZ?Do not drive a car, operate machinery, or engage in other tasks requiring alertness until you know how metoprolol/HCTZ affects you.
Do not drink alcohol while you are taking metoprolol/HCTZ.
Do not stop taking metoprolol/HCTZ abruptly without first talking to your doctor.
What are possible food and drug interactions associated with Metoprolol/HCTZ?If metoprolol/HCTZ is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining metoprolol/HCTZ with the following: alcohol, anti-HIV medications (such as ritonavir), antihistamines (such as diphenhydramine), certain antidepressants (such as bupropion, fluoxetine, or paroxetine), certain antifungals (such as terbinafine), certain antipsychotics (such as thioridazine), cholestyramine, clonidine, colestipol, corticosteroids (such as prednisone), digoxin, insulin, lithium, medications for irregular heartbeat (such as propafenone or quinidine), medications for malaria (such as hydroxychloroquine or quinidine), medications for stomach ulcers (such as cimetidine), methyldopa, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as indomethacin), norepinephrine, or reserpine.
What are the possible side effects of Metoprolol/HCTZ?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: allergic reactions, blurred vision, constipation, decreased heartbeat, diarrhea, discoloration of your skin, dizziness, drowsiness, dry mouth, ear pain, "flu-like" symptoms, headache, impotence, indigestion, loss of appetite, low blood pressure, muscle pain, nausea, nightmares, shortness of breath, sweating, swelling, tiredness, vomiting, wheezing
Can I receive Metoprolol/HCTZ if I am pregnant or breastfeeding?The effects of metoprolol/HCTZ during pregnancy and breastfeeding are unknown. Metoprolol/HCTZ can be found in your breast milk if you take it while breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Metoprolol/HCTZ?If you miss a dose of metoprolol/HCTZ, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store Metoprolol/HCTZ?Store at room temperature. Protect from moisture.