What is Mexiletine?Mexiletine treats irregular heartbeat conditions known as "ventricular arrhythmias." Because Mexiletine may worsen irregular heartbeats in some patients, it is only used for serious, life-threatening conditions. Mexiletine is usually first given in the hospital so that your doctor can closely monitor your heart's response.
What is the most important information I should know about Mexiletine?You should only take Mexiletine if you have been diagnosed by your doctor as having a life-threatening arrhythmia (irregular heartbeat).
Mexiletine may cause acute liver injury within the first few weeks of use; your doctor may monitor your liver function by performing simple blood tests.
Use cautiously if you have low blood pressure, congestive heart failure, any seizure disorder, or liver impairment or disease. In some cases, Mexiletine can worsen arrhythmias; your doctor may closely monitor your heart's function.
Rarely, Mexiletine can lower the counts of certain cells in your blood necessary to fight infections and form clots. Tell your doctor immediately if you experience any infection, prolonged bleeding, or bloody stool while taking Mexiletine.
Who should not take Mexiletine?Do not take Mexiletine if you have been diagnosed with conditions called "cardiogenic shock" or "pre-existing second- or third-degree AV block" (if you do not have a pacemaker).
What should I tell my doctor before I take the first dose of Mexiletine?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Mexiletine. Also, talk to your doctor about your complete medical history, especially if you have liver impairment or disease, congestive heart failure, or low blood pressure.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The usual initial dosage is 200-300 milligrams (mg) taken every 8 hours as monitored by your doctor. Your individual dose may be lower or higher than this based on your condition. If satisfactory response has not been achieved at 300 mg every 8 hours, then your dose may be raised to 400 mg every 8 hours. The dose should not exceed 1200 mg per day.
How should I take Mexiletine?Take Mexiletine at the same time every day with food or an antacid to reduce its possible side effects.
What should I avoid while taking Mexiletine?Avoid consuming excessive amounts of caffeine, as Mexiletine may prolong its effects in your body.
What are possible food and drug interactions associated with Mexiletine?If Mexiletine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Mexiletine with the following: caffeine, cimetidine, fluvoxamine, phenobarbital, propafenone, rifampin, and theophylline.
What are the possible side effects of Mexiletine?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: upset stomach, nausea, vomiting, heartburn, diarrhea, constipation, lightheadedness, tremor or shakiness, problems with coordination, changes in sleeping patterns, nervousness, weakness or numbness, headache, blurred vision or vision changes, rash, water retention, irregular heartbeat, chest pain
Can I receive Mexiletine if I am pregnant or breastfeeding?The effects of Mexiletine during pregnancy are not well established. Mexiletine can be found in breast milk. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Mexiletine?If you miss a dose of Mexiletine, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once. If you are unsure, ask your doctor or pharmacist for advice..
How should I store Mexiletine?Mexiletine should be stored at room temperature.
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