What is Naloxone?Naloxone is a medicine used to completely or partially block opioid depression, including abnormally slow and shallow breathing caused by certain opioid medications, and it can be used to diagnose opioid overdose. This medicine can be used in combination with other medicines to increase blood pressure in the management of severely low blood pressure due to sepsis (a bloodstream infection). Naloxone is administered intramuscularly (injected into the muscle), intravenously (through a vein in your arm), or subcutaneously (just below the skin).
What is the most important information I should know about Naloxone?Naloxone can cause opioid withdrawal if you are physically dependent on opioids. If this occurs, you can experience body aches, diarrhea, fever, increased heartbeat, runny nose, sneezing, sweating, yawning, nausea or vomiting, nervousness, restlessness, irritability, shivering, trembling, abdominal cramps, weakness, or increased blood pressure.
If your newborn baby is physically dependent on opioids and naloxone is administered, your child may experience abnormally active reflexes, excessive crying, or seizures.
Naloxone is not habit-forming and does not cause physical dependence.
Who should not take Naloxone?Your doctor will not administer naloxone to you if you are allergic to it or any of its ingredients, or for abnormally slow and shallow breathing caused by non-opioid medications.
What should I tell my doctor before I take the first dose of Naloxone?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with naloxone. Also, talk to your doctor about your complete medical history, especially if you have heart problems, kidney or liver disease, or lung problems.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults and children: Your doctor will administer the appropriate dose for you based on your condition.
If you are elderly, your doctor will adjust your dose appropriately.
How should I take Naloxone?Your doctor will administer naloxone to you.
What should I avoid while taking Naloxone?Do not miss your scheduled follow-up appointments with your doctor.
What are possible food and drug interactions associated with Naloxone?No significant interactions have been reported with naloxone at this time. However, always tell your doctor about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.
What are the possible side effects of Naloxone?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: agitation, changes in your blood pressure, flushing, hallucinations, heart attack, injection-site reactions, irregular or increased heartbeat, nausea, numbness in skin, seizures, shortness of breath, slowed breathing, sweating, trembling, vomiting
Can I receive Naloxone if I am pregnant or breastfeeding?The effects of naloxone during pregnancy and breastfeeding are unknown. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Naloxone?Naloxone should be given under special circumstances determined by your doctor.
How should I store Naloxone?Your doctor will store this medication for you.