Generic Name: Phenelzine sulfate

  • What is Nardil?

    Nardil is used to treat depression. Nardil is often used in the treatment of depression associated with anxiety, phobias, or neurotic behaviors.
  • What is the most important information I should know about Nardil?

    Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults when the medicine is first started. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar disorder (also called manic-depressive illness) or suicidal thoughts or actions.

    Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is first started or when the dose is changed.

    Call the doctor right away to report new or sudden changes in mood, behavior, thoughts, or feelings. Signs to watch for include new or worsening depression, new or worsening anxiety, agitation, insomnia, hostility, panic attacks, restlessness, extreme hyperactivity, and suicidal thinking or behavior.

    Keep all follow-up visits as scheduled, and call the doctor between visits as needed, especially if you have concerns about symptoms.

    Nardil is a monoamine oxidase inhibitor (MAOI). This class of drugs, including Nardil, can cause a sudden, large increase in blood pressure (hypertensive crisis) if you consume foods and drinks that contain high amounts of tyramine.

    You should use caution when taking Nardil if you have diabetes, schizophrenia, or epilepsy.

    Nardil may also cause low blood pressure, which can lead to dizziness, lightheadedness, or fainting.

    Nardil should be discontinued at least 10 days before undergoing any type of surgery that requires anesthesia or numbing agents.

    You should wait at least 14 days between the discontinuation of Nardil and starting therapy with another antidepressant of any class.

  • Who should not take Nardil?

    You should not take Nardil if you are allergic or sensitive to phenelzine sulfate or any other ingredient in Nardil; if you have a condition known as pheochromocytoma, congestive heart failure, severe kidney impairment or disease, liver disease, or abnormal liver function tests.
  • What should I tell my doctor before I take the first dose of Nardil?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Nardil. Also, talk to your doctor about your complete medical history, especially if you have a history or family history of suicide or suicidal thoughts, bipolar disorder, liver or kidney disease, heart disease, epilepsy, or schizophrenia.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual starting dose is 15 milligrams (mg) taken three times a day. Your doctor will likely increase your daily dose over the course of several weeks to 60 mg to 90 mg per day in divided daily doses. After maximum benefit from Nardil is achieved, dosage should be reduced slowly over several weeks. Maintenance dose may be as low as one tablet, 15 mg, a day or every other day, and should be continued for as long as required.

  • How should I take Nardil?

    Nardil can be taken with or without food (see the next section for a list of foods to avoid) and should be taken at the same time every day.
  • What should I avoid while taking Nardil?

    While on Nardil, avoid tyramine-rich foods such as dried or aged meats (sausages/salami), fava beans, aged cheeses, beer on tap, yeast, sauerkraut, and soybean products.

    Avoid taking any cold and cough preparations (including those containing dextromethorphan); nasal decongestants (tablets, drops, or spray); allergy, sinus and asthma medications; weight-loss drugs; or products containing L-tryptophan.

    Avoid the concurrent use of sympathomimetic drugs (including amphetamines, cocaine, methylphenidate, dopamine, epinephrine, and norepinephrine) or related compounds (including methyldopa, L-dopa, L-tryptophan, L-tyrosine, and phenylalanine).

  • What are possible food and drug interactions associated with Nardil?

    If Nardil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Nardil with the following: allergy medicines, amitriptyline, amoxapine, appetite suppressants, asthma medicines, carbamazepine, citalopram, clomipramine, cold and cough preparations, cyclobenzaprine, decongestants, desipramine, dexfenfluramine, dextromethorphan, doxepin, fluoxetine, fluvoxamine, guanethidine, imipramine, products containing L-tryptophan, maprotiline, meperidine, mirtazapine, nortriptyline, paroxetine, perphenazine and amitriptyline, protriptyline, rauwolfia alkaloids, sertraline, trimipramine, and venlafaxine.

    Nardil should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and beta blockers, since low blood pressure may result.

  • What are the possible side effects of Nardil?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: dizziness, headache, drowsiness, trouble sleeping, fatigue, muscle twitching, trouble balancing, psychosis, decreased sexual ability, dry mouth, constipation, weight gain, trouble urinating, rash, itching skin, weakness, blurred vision, glaucoma, sweating, liver injury

  • Can I receive Nardil if I am pregnant or breastfeeding?

    The effects of Nardil during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Nardil?

    You should not double your dose of Nardil. Skip the missed dose and return to your normal dosing schedule.
  • How should I store Nardil?

    Store at room temperature.