Generic Name: Thiothixene

  • What is Navane?

    Navane is an antipsychotic medication that is used to treat schizophrenia.
  • What is the most important information I should know about Navane?

    Navane can cause tardive dyskinesia, a serious, sometimes irreversible movement disorder that causes involuntary movements of muscles. The risk for tardive dyskinesia is higher in the elderly and for women. Tell your doctor immediately if you experience any involuntary muscle movements while taking Navane.

    Navane can also cause another serious sometime fatal disorder known as neuroleptic malignant syndrome, characterized by muscle stiffness, increased body temperature, sweating, changes in mood or consciousness, and a rapid or irregular heartbeat. If you experience any of these symptoms while taking Navane, seek emergency medical attention immediately.

    Navane should be used with caution in patients who might be exposed to extreme heat or who are receiving atropine. Navane should also be used with caution in patients with cardiovascular disease. Careful adjustment of dosage is indicated when Navane is used with other CNS depressants.

  • Who should not take Navane?

    You should not take Navane if you are sensitive or allergic to any ingredient in Navane.

    Navane should not be administered to anyone in a comatose state.

    Do not take Navane if you are taking a sleep aid or any other substance that slows your central nervous system.

    If you have had circulatory system collapse or if you have an abnormal bone marrow or blood condition, you should not take Navane.

  • What should I tell my doctor before I take the first dose of Navane?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Navane. Also, talk to your doctor about your complete medical history, especially if you have a history of tardive dyskinesia or neuroleptic malignant syndrome (see "What is the most important information I should know about this medication?").

    Let your doctor know if you have liver disease, breast cancer, seizures, high or low blood pressure, depression, lupus, heart disease, or if you are or have been alcohol dependent. Also, let your doctor know if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    The use of Navane in children under 12 years of age is not approved.

    The usual daily dose is 20-30 milligrams (mg) once daily. Dosage is individually adjusted depending on the severity of the patient's disease state. Initially, small doses are used. Further gradual increase is based on patient response and the optimal effect of the drug.

    For Milder Conditions

    Adults and children 12 years and older: The usual starting dosage is 2 mg taken 3 times a day. Your doctor may increase the dose to a total of 15 mg a day.

    For More Severe Conditions

    Adults and Children 12 years and older: The usual starting dosage is 5 mg taken two times a day. Your doctor may increase this dose to a total of 60 mg a day. Exceeding a total daily dose of 60mg rarely increases the beneficial response.

  • How should I take Navane?

    Navane can be taken with or without food and should be taken at the same time(s) every day. Take Navane as prescribed by your doctor.
  • What should I avoid while taking Navane?

    You should not drive a car or operate heavy machinery until you know how Navane will affect you.

    When taking Navane, avoid becoming dehydrated and exposing yourself to very hot environments.

    When taking Navane, you should avoid consumption of alcohol as it may intensify the side effects of the drug.

  • What are possible food and drug interactions associated with Navane?

    If Navane is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Navane with the following: anticholinergic medications such as atropine, antihistamines, barbiturates, blood pressure medications, carbamazepine, opiates, and tricyclic antidepressants.
  • What are the possible side effects of Navane?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: allergic rash, blurred vision, dizziness, drowsiness, dry mouth, immobility, increased heart rate, involuntary muscle contractions, involuntary muscle movements, liver damage, low blood pressure, menstrual irregularities, muscle restlessness, muscle stiffness, muscle tremors, blood disorders

    Navane may cause damage to your liver or your eyes. Some of the warning signs of liver damage include nausea, vomiting, fatigue, loss of appetite, itching, yellow coloring of skin or eyes (jaundice), flu-like symptoms, and dark urine. If you experience any of these symptoms, call your doctor right away. Also, contact your doctor right away if you experience any changes in your vision.

  • Can I receive Navane if I am pregnant or breastfeeding?

    The effects of Navane during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Navane?

    You should not double your dose of Navane. Skip the missed dose and return to your normal dosing schedule.
  • How should I store Navane?

    Store at room temperature.