Generic Name: Nefazodone

  • What is this medication and its most common uses?

    Nefazodone is a medicine called a serotonin and norepinephrine reuptake inhibitor (SNRI). It is used to treat depression.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Nefazodone is thought to work by increasing the activity of chemicals in your brain called serotonin and norepinephrine. By increasing serotonin and norepinephrine, nefazodone may help improve your symptoms.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Nefazodone has been shown to relieve symptoms associated with depression, as measured by appropriate symptom rating scales that are commonly used by healthcare providers to evaluate the effectiveness of the medicine in people with depression.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take nefazodone exactly as your healthcare provider has prescribed, even if you do not feel better right away.

    How do I know it is working?

    Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Nefazodone can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening or suicidal/unusual behavior after you start taking nefazodone or start a new dose of nefazodone. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, thoughts about suicide or dying, or if you have new symptoms or seem to be feeling worse.

    Rare, life-threatening cases of liver problems have been reported with nefazodone. Call your healthcare provider immediately if you develop symptoms such as yellowing of your skin or the whites of your eyes, unusually dark urine, loss of appetite that lasts for several days, or nausea or lower stomach pain while taking nefazodone.

    More common side effects may include: drowsiness, dry mouth, nausea, dizziness, constipation, weakness, lightheadedness, blurred vision, confusion, changes in your vision.

    Less common side effects may include:

    Manic episodes with symptoms such as greatly increased energy, severe trouble sleeping, racing thoughts, reckless behavior, excessive happiness or irritability, or talking more or faster than usual.

    Nefazodone may cause seizures or priapism (painful, prolonged erections).

  • Who should not take this medication?

    Do not take nefazodone if you are allergic to it, any of its ingredients, or to other similar medicines (such as trazodone).

    Do not take nefazodone if you are taking terfenadine, astemizole, cisapride, pimozide, carbamazepine, or triazolam.

    Do not take nefazodone if you have taken it in the past and experienced liver problems.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, vitamin supplements, and herbal medications you are taking before beginning treatment with nefazodone. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or heart problems; had a heart attack or stroke, a manic episode, a suicide attempt, or seizures; or are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The recommended starting dose is 200 milligrams per day, taken in two divided doses. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

    If you are elderly, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take nefazodone exactly as prescribed by your healthcare provider. Do not change your dose or stop taking nefazodone without first talking to your healthcare provider.

    Take nefazodone at the same time every day. Take it with or without food.

  • What should I avoid while taking this medication?

    Do not drive, operate heavy machinery, or engage in other dangerous activities until you know how nefazodone affects you.

    Do not drink alcohol while you are taking nefazodone.

  • What are the possible food and drug interactions associated with this medication?

    If nefazodone is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Nefazodone may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of nefazodone during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of nefazodone, skip the one you and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.