What is NeoProfen?NeoProfen is used to close a hole in the heart (patent ductus arteriosus, or PDA) in premature infants weighing between 500 grams (g) and 1500 g who are no more than 32 weeks gestational age when normal medical management is ineffective.
What is the most important information I should know about NeoProfen?NeoProfen, like other nonsteroidal anti-inflammatory drugs (NSAIDs), may lengthen bleeding time. The infant should be carefully observed for signs and symptoms of bleeding.
This drug may also change the normal signs and symptoms of infection. The physician should use the drug with extra care when an infection is present or if an infant is at risk of infection.
NeoProfen should be administered carefully to avoid extravascular injection or leakage of the medicine in surrounding tissue; the solution may be irritating to the tissue.
Who should not take NeoProfen?Preterm infants should not begin treatment with NeoProfen if they have any of the following: a proven or suspected untreated infection, heart disease that requires opening of the patent ductus arteriosus (PDA) in order to maintain proper pulmonary or systemic blood flow (eg, pulmonary atresia, severe tetralogy of Fallot, severe narrowing of the aorta), bleeding problems (eg, bleeding within the brain, gastrointestinal bleeding), thrombocytopenia (a decrease of platelets in the blood), blood clotting problems, necrotizing enterocolitis (where portions of the bowel undergo tissue death), and kidney problems.
What should I tell my doctor before I take the first dose of NeoProfen?Tell your doctor about all prescription, over-the-counter, and herbal medications your child is taking.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
NeoProfen is first given at 10 milligrams (mg) per 2.2 pounds of body weight, followed by two doses of 5 mg per 2.2 pounds of body weight, after 24 and 48 hours. All doses should be based on birth weight.
How should I take NeoProfen?NeoProfen will be given to your child in a hospital setting, through an IV.
If the PDA closes or is reduced in size after the first course of NeoProfen, no further doses are necessary. If the PDA does not close or re-opens, then a second course of NeoProfen, alternative therapy, or surgery may be necessary.
What should I avoid while taking NeoProfen?Avoid administering Neoprofen in the same intravenous (IV) line as total parenteral nutrition (TPN). If it is necessary to give NeoProfen in the same line, then the TPN should be turned off 15 minutes prior to giving Neoprofen and should not be restarted until 15 minutes after NeoProfen has been administered. Your healthcare professional will inform you of any other precautions for your child.
What are possible food and drug interactions associated with NeoProfen?There are currently no known drug interactions associated with NeoProfen. However, it is important to notify your physician of all prescription and nonprescription medications your infant is taking.
What are the possible side effects of NeoProfen?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: anemia, bleeding, blood in urine, breathing problems, gastrointestinal disorders, kidney problems, low sugar levels in the blood, respiratory infection, skin lesions or irritation, septic infection, urinary tract infection
Can I receive NeoProfen if I am pregnant or breastfeeding?NeoProfen is only used in infants. It is not indicated for pregnant or breastfeeding females.
What should I do if I miss a dose of NeoProfen?You will not be administering the dose of NeoProfen to your infant. Your infant's healthcare professional will be responsible for giving the appropriate doses.
How should I store NeoProfen?This medication is usually stored by a healthcare professional at room temperature and protected from light. NeoProfen vials should be stored in the carton until contents have been used.