Neupogen

Generic Name: Filgrastim

  • What is Neupogen?

    Neupogen is a man-made form of granulocyte colony-stimulating factor (G-CSF), which is made using the bacteria E. coli. G-CSF is a substance naturally produced by the body. It stimulates the growth of neutrophils, a type of white blood cell important in the body's fight against infection.

    Neupogen is used to treat neutropenia, a condition where the body makes too few neutrophils. Neutropenia may be a long-standing condition where your body does not make enough neutrophils, or it may be caused by drugs used to treat cancer.

  • What is the most important information I should know about Neupogen?

    Neupogen may reduce your chance of getting an infection, but does not prevent all infections. You can still get an infection during the short time when your neutrophil levels are low. Be alert for some of the common signs or symptoms of infection, such as fever, chills, rash, sore throat, diarrhea, or redness, swelling, or pain around a cut or sore. If you have any of these signs or symptoms during treatment with Neupogen, tell your doctor immediately.

    If you have a sickle cell disorder, make sure that you tell your doctor before you start taking Neupogen. If you have a sickle cell crisis after getting Neupogen, tell your doctor right away.

    If you are receiving Neupogen because you are also receiving chemotherapy, the last dose of Neupogen should be injected at least 24 hours before your next dose of chemotherapy.

    You could have a reaction at an injection site. If there is a lump, swelling, or bruising at an injection site that does not go away, call your doctor.

  • Who should not take Neupogen?

    Do not take Neupogen if you are allergic to other medicines made using the bacteria E. coli.

  • What should I tell my doctor before I take the first dose of Neupogen?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Neupogen. Also, talk to your doctor about your complete medical history, especially if you have sickle cell disorder, a blood cell disorder, chronic myeloid leukemia, myelodysplasia (also called "preleukemia"), or if you are receiving chemotherapy or radiation treatment.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Your doctor will determine the correct dosage of Neupogen for you based on weight and your condition.

  • How should I take Neupogen?

    A nurse or other trained health professional may give you this medicine. This medicine is given as a shot under your skin or into a vein.

    You may be taught how to give this medicine at home. Make sure you understand all of the instructions before giving yourself an injection.

    Neupogen should be injected at the same time each day.

    This medicine comes with patient instructions. Read and follow these instructions carefully.

    You must always use the correct dose of Neupogen. Too little Neupogen may not protect you against infections, and too much Neupogen may cause too many neutrophils to be in your blood. Your doctor will determine your correct dose based on your body weight.

    If you are giving someone else Neupogen injections, it is important that you know how to inject Neupogen, how much to inject, and how often to inject Neupogen.

    Neupogen is available as a liquid in vials or in prefilled syringes. When you receive your Neupogen, always check to see that the name "Neupogen" appears on the package and vial or prefilled syringe label, the expiration date on the vial or prefilled syringe label has not passed, the strength of the Neupogen is the same as your doctor prescribed, and that the Neupogen liquid in the vial or in the prefilled syringe is clear and colorless.

    If you are using vials of Neupogen, only use the syringe that your doctor prescribes.

    Your doctor or nurse will give you instructions on how to measure the correct dose of Neupogen. This dose will be measured in milliliters. You should only use a syringe that is marked in tenths of milliliters, or mL (for example, 0.2 mL). The doctor or nurse may refer to an mL as a cc (1 mL = 1 cc). If you do not use the correct syringe, you could receive too much or too little Neupogen.

    Only use disposable syringes and needles. Use the syringes only once and dispose of them as instructed by your doctor or nurse.

    Ask your doctor if you have any questions about the preparation, disposal, or administration of Neupogen.

  • What should I avoid while taking Neupogen?

    Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using Neupogen.

  • What are possible food and drug interactions associated with Neupogen?

    If Neupogen is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Neupogen with lithium as you may need more frequent blood tests.

  • What are the possible side effects of Neupogen?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: aching in the bone and muscles, nausea, vomiting, bone pain, hair loss, diarrhea, fever, digestive tract inflammation, fatigue, loss of appetite, breathing difficulty, headache, cough, skin rash, chest pain

    Stop using Neupogen and call your doctor if you have any of these serious side effects: pain in the left upper stomach area or left shoulder tip area, a rash over the whole body, shortness of breath, wheezing, dizziness, swelling around the mouth or eyes, fast pulse, sweating, trouble breathing, a fast rate of breathing

  • Can I receive Neupogen if I am pregnant or breastfeeding?

    Neupogen has not been studied in pregnant women, and its effects on unborn babies are not known. If you take Neupogen while you are pregnant, it is possible that small amounts of it may get into your baby's blood. It is not known if Neupogen can get into human breast milk.

    If you are pregnant, think you may be pregnant, plan to become pregnant, or are breastfeeding, you should tell your doctor before using Neupogen.

  • What should I do if I miss a dose of Neupogen?

    If you miss a dose, contact your doctor.

  • How should I store Neupogen?

    Neupogen should be stored in the refrigerator, but not in the freezer. Avoid shaking Neupogen. If Neupogen is accidentally frozen, allow it to thaw in the refrigerator before giving the next dose. However, if it is frozen a second time, do not use it and contact your doctor or nurse for further instructions.

    Neupogen can be left out at room temperature for up to 24 hours. Do not leave Neupogen in direct sunlight. If you have any questions about storage or how to carry Neupogen when you travel, contact your doctor, nurse or pharmacist.

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I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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