Nexavar

Generic Name: Sorafenib

  • What is Nexavar?

    Nexavar is a cancer treatment for adults with kidney cancer (renal cell carcinoma) and liver cancer (hepatocellular carcinoma).
  • What is the most important information I should know about Nexavar?

    Nexavar may cause birth defects or death in unborn babies. Women should not get pregnant while taking Nexavar. Men and women should use effective birth control during treatment with Nexavar and for at least 2 weeks after stopping treatment. Talk with your doctor about effective birth control methods.

    Nexavar may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

    Nexavar may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.

    Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Nexavar.

    Do not suddenly stop taking Nexavar, even if you feel better.

  • Who should not take Nexavar?

    Do not take Nexavar if you are allergic to sorafenib (the active ingredient) or any of the other ingredients.
  • What should I tell my doctor before I take the first dose of Nexavar?

    Tell your doctor if you have kidney problems (in addition to cancer), liver problems (in addition to cancer), high blood pressure, bleeding problems, heart problems or chest pain, or if you are pregnant or breastfeeding.

    Also, you should tell your doctor about all prescription, over-the-counter, and herbal medications you are on, to prevent an interaction with Nexavar. Tell your doctor if you are taking warfarin.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    The recommended dose of Nexavar is 400 milligrams (mg) (2 tablets of 200 mg) taken twice daily. A total of 4 tablets should be taken daily.

  • How should I take Nexavar?

    Take doses of Nexavar on an empty stomach (either 1 hour before or 2 hours after a meal). Swallow Nexavar whole. Do not break, crush, or chew before swallowing. Take Nexavar with a full glass of water (8 oz/240 mL). Treatment with this medication should continue until you are no longer benefiting from it.
  • What should I avoid while taking Nexavar?

    While on Nexavar and for 2 weeks after stopping treatment, use appropriate birth control in order to prevent pregnancy.

    Do not break, crush, or chew before swallowing; swallow Nexavar tablets whole.

    Avoid situations in which bruising or injury may occur.

    Do not suddenly stop taking Nexavar, even if you feel better.

  • What are possible food and drug interactions associated with Nexavar?

    If Nexavar is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Nexavar with the following: doxorubicin (Adriamycin, Doxil); irinotecan (Camptosar); and warfarin (Coumadin).
  • What are the possible side effects of Nexavar?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: birth defects or fetal death, heart problems, high blood pressure, loss of appetite, mouth sores, nausea, numbness, skin problems, thinning hair, tingling on the hands or feet, vomiting, weakness

    Nexavar may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

    Nexavar may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.

  • Can I receive Nexavar if I am pregnant or breastfeeding?

    Nexavar may cause birth defects or death to an unborn child. Do not take Nexavar if you are pregnant, plan to become pregnant, or are nursing. Do not breast feed while you are taking Nexavar because this drug may pass into breast milk. If you think you may be pregnant, contact your doctor.
  • What should I do if I miss a dose of Nexavar?

    If you miss a dose of Nexavar, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
  • How should I store Nexavar?

    Store Nexavar at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Nexavar out of the reach of children.