Generic Name: Desipramine hydrochloride

  • What is Norpramin?

    Norpramin is used to treat the symptoms of depression.
  • What is the most important information I should know about Norpramin?

    Norpramin is not approved for use in children.

    Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults when the medicine is first started. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar disorder (also called manic-depressive illness) or suicidal thoughts or actions.

    Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is first started or when the dose is changed.

    Call the doctor right away to report new or sudden changes in mood, behavior, thoughts, or feelings. Signs to watch for include new or worsening depression, new or worsening anxiety, agitation, insomnia, hostility, panic attacks, restlessness, extreme hyperactivity, and suicidal thinking or behavior.

    Keep all follow-up visits as scheduled, and call the doctor between visits as needed, especially if you have concerns about symptoms.

  • Who should not take Norpramin?

    Do not take Norpramin if you are allergic to it or any of its components.

    Do not take Norpramin if you have recently had a heart attack.

    If you are taking or have taken antidepressant medications known as monoamine oxidase inhibitors (MAOIs) within the last 14 days, do not take Norpramin.

    If you are planning to have elective surgery, make sure that your doctor is aware that you are taking Norpramin. It should be discontinued as soon as possible prior to surgery.

  • What should I tell my doctor before I take the first dose of Norpramin?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Norpramin. Also, talk to your doctor about your complete medical history, especially if you have heart disease, a history of heart attack, stroke, seizures, bipolar disorder (manic-depression), schizophrenia or other mental illness, liver disease, overactive thyroid, high blood sugar, increased pressure in the eyes (glaucoma), or problems with urination.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose ranges from 100 to 200 milligrams (mg) per day, taken in one dose or divided into smaller doses. If needed, dosages may gradually be increased to 300 mg a day. Dosages above 300 mg per day are not recommended.

    Older adults and adolescents: The usual dose ranges from 25 to 100 mg per day. If needed, dosages may gradually be increased to 150 mg a day. Doses above 150 mg per day are not recommended.

  • How should I take Norpramin?

    Norpramin should be taken exactly as prescribed. Do not stop taking Norpramin if you feel no immediate effect. It can take up to 2 or 3 weeks for improvement to begin.

    Norpramin can cause dry mouth. Sucking hard candy or chewing gum can help this problem.

  • What should I avoid while taking Norpramin?

    Norpramin may increase your skin's sensitivity to sunlight. Overexposure could cause rash, itching, redness, or sunburn. Avoid direct sunlight or wear protective clothing.

    This drug may impair your ability to drive a car or operate potentially dangerous machinery. Do not participate in any activities that require full alertness if you are unsure about your ability.

    Avoid drinking alcohol. It can cause dangerous side effects when taken together with Norpramin.

  • What are possible food and drug interactions associated with Norpramin?

    If Norpramin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Norpramin with the following: alcohol, antidepressants (including MAOIs and SSRIs), cimetidine, drugs that improve breathing, muscle relaxants, guanethidine, sedatives/hypnotics, sertraline, and thyroid medications.
  • What are the possible side effects of Norpramin?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: anxiety, confusion, dizziness, dry mouth, frequent urination or problems urinating, high blood pressure, hallucinations, hives, impaired coordination, irregular heartbeat, low blood pressure, numbness, rapid heartbeat, sensitivity to sunlight, sex drive changes, tingling, tremors

  • Can I receive Norpramin if I am pregnant or breastfeeding?

    The effects of Norpramin during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Norpramin?

    If you do miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.
  • How should I store Norpramin?

    Store at room temperature and protect from excessive heat.