Noxafil

Generic Name: Posaconazole

  • What is this medication and its most common uses?

    Noxafil is a medicine that is used to prevent certain invasive fungal infections (infections that can spread throughout the body) in patients with a weak immune system because of medicines or diseases (such as stem cell transplantation with graft-vs.-host disease or chemotherapy for blood cancers). Noxafil is also used to treat fungal infections in the mouth or throat area (known as "thrush") as initial treatment or resistant toother antifungal medicines (such as itraconazole and/or fluconazole) have failed. Noxafil is available as an oral suspension.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Noxafil works by stopping the growth of fungus, thereby treating your infection.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Noxafil may help relieve your symptoms and eliminate the infection.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Noxafil exactly as your healthcare provider has prescribed.

    How do I know it is working?

    You may start to notice an improvement in your symptoms. This is a good indicator that your medication is working. Your healthcare provider may ask you questions and order tests to assess how well your infection is being treated.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: diarrhea, fever, headache, nausea, vomiting, coughing.

    Less common side effects may include:

    Changes in your heart rate or rhythm, especially in people who have certain heart conditions, or who take certain medications.

    Liver problems, with symptoms such itching, yellowing of your skin or the whites of your eyes, flu-like symptoms, tiredness, or nausea or vomiting.

    Severe diarrhea or vomiting.

  • Who should not take this medication?

    Do not take Noxafil if you are allergic to it or any of its ingredients.

    Do not take Noxafil in combination with certain cholesterol-lowering medicines known as "statins" (such as atorvastatin, lovastatin, or simvastatin), ergot alkaloids (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine, or methylsergide), pimozide, quinidine, or sirolimus.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Noxafil. Also, talk to your healthcare provider about your complete medical history, especially if you have a history of liver problems, abnormal heart rate or rhythm, ever had an allergic reaction to other antifungal medicines (such as ketoconazole or fluconazole), or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Prevention of Invasive Fungal Infections

    Adults and children ≥13 years: The recommended dose is 200 milligrams (mg) (5 milliliters [mL]) three times a day.

    Thrush of the Mouth or Throat

    Adults and children ≥13 years: The recommended dose is 100 mg (2.5 mL) twice a day on the first day, then 100 mg (2.5 mL) once a day for 13 days.

    Thrush of the Mouth or Throat Resistant to Other Antifungal Medicines

    Adults and children ≥13 years: The recommended dose is 400 mg (10 mL) twice a day.

  • How should I take this medication?

    Take Noxafil exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Noxafil without first talking to your healthcare provider.

    Shake Noxafil bottle well before use.

    Take each dose of Noxafil during or within 20 minutes of a full meal. If you cannot eat a full meal, take Noxafil with a liquid nutritional supplement (such as "Boost") or an acidic carbonated beverage (such as ginger ale).

    A measured dosing spoon is provided, marked for doses of 2.5 mL and 5 mL. Rinse the spoon with water after each administration and before storage.

  • What should I avoid while taking this medication?

    Do not take Noxafil with any other medicines without first talking to your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If Noxafil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Noxafil with any of the following: alprazolam, anti-HIV medications (such as atazanavir, efavirenz, fosamprenavir, or ritonavir), blood pressure/heart medications known as calcium channel blockers (such as diltiazem, nifedipine, or verapamil), certain statins, cimetidine, cyclosporine, digoxin, ergot alkaloids, esomeprazole, glipizide, metoclopramide, midazolam, phenytoin, pimozide, quinidine, rifabutin, sirolimus, tacrolimus, triazolam, vincristine, or vinblastine.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of Noxafil during pregnancy and breastfeeding are unknown. Do not take Noxafil if you are breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Noxafil, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

Meet the Pharmacists

I'm Beth Isaac, PharmD. Welcome to PDR Health!

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