Nucynta ER

Generic Name: Tapentadol

  • What is Nucynta ER?

    Nucynta ER is a narcotic pain medicine that contains tapentadol. Nucynta ER is used to treat moderate to severe pain when a continuous, around-the-clock narcotic painkiller is needed for an extended period of time.

    Nucynta ER is a federally controlled substance because it has abuse potential.

  • What is the most important information I should know about Nucynta ER?

    Nucynta ER has abuse potential. Mental and physical dependence can occur with the use of Nucynta ER when it is used improperly for long periods of time.

    Nucynta ER can cause serious breathing problems that can become life-threatening, especially when it is used in the wrong way for long periods of time. Tell your doctor if you have any lung or breathing problems (such as asthma); your doctor will monitor you.

    Do not use Nucynta ER for short-term pain relief from injuries, surgery, or pain that you only have once in a while ("as needed").

    Swallow Nucynta ER tablets whole. Do not break, split, chew, dissolve, or crush the tablets before swallowing. Do not inject the contents; if you do, Nucynta ER can be released too fast. This can cause you to have trouble breathing and lead to death. Tell your doctor if you cannot swallow tablets whole.

    Nucynta ER can impair your mental and physical abilities. Do not drive, operate machinery, or do other dangerous activities until you know how Nucynta ER affects you. Also, do not drink alcohol or take other medications that can affect your brain (such as medications that make you drowsy and narcotic painkillers) while using Nucynta ER.

    Prevent theft, misuse, or abuse by keeping Nucynta ER in a safe place to protect it from being stolen. Nucynta ER can be a target for people who misuse or abuse prescription medicines or street drugs. Also, do not give Nucynta ER to anyone else, even if they have the same symptoms you have because it can harm them or even cause death. Selling or giving away this medicine is against the law.

  • Who should not take Nucynta ER?

    Do not take Nucynta ER if you are allergic to it, any of its ingredients, or if you are having an asthma attack, have severe asthma, trouble breathing, or lung problems.

    Do not take Nucynta ER if you have paralytic ileus (impairment of the small intestines).

    Do not take Nucynta ER within 14 days of taking a monoamine oxidase inhibitor (MAOI), a class of drugs used to treat depression and other psychiatric conditions (such as phenelzine).

  • What should I tell my doctor before I take the first dose of Nucynta ER?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Nucynta ER. Also, talk to you doctor about your complete medical history, especially if you have breathing or lung problems; brain problems or head injury; paralytic ileus; liver or kidney problems; adrenal gland problems; thyroid problems; seizures; pancreas or gallbladder problems; urination or prostate problems; constipation; severe scoliosis (curving of the spine) that affects your breathing; low blood pressure; alcoholism; mental problems, such as depression, anxiety, or hallucinations; history of or a present drug abuse or addiction problem; a family history of drug abuse or addiction problem; plan to have surgery; or are pregnant or breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults ≥18 years: The recommended starting dose is 50 milligrams (mg) twice a day, given approximately every 12 hours. Your doctor will prescribe the appropriate dose for you based on your condition, previous pain medication, and tolerance for narcotic painkillers.

  • How should I take Nucynta ER?

    Take Nucynta ER exactly as prescribed by your doctor. Do not change your dose without speaking to your doctor.

    Swallow Nucynta ER tablets whole. Do not break, split, chew, dissolve, or crush the tablets before swallowing. Do not inject the contents. Also, do not pre-soak, lick, or wet the tablet before placing it in your mouth.

    Do not discontinue Nucynta ER abruptly. Your doctor should provide you with a dose schedule to gradually discontinue the medication. This will help to avoid withdrawal symptoms.

    Dispose all unused tablets by flushing them down the toilet.

  • What should I avoid while taking Nucynta ER?

    Do not drink alcohol while you are taking Nucynta ER. Alcohol can increase your chance of having dangerous side effects.

    Do not drive, operate machinery, or do other dangerous activities until you know how Nucynta ER affects you.

  • What are possible food and drug interactions associated with Nucynta ER?

    If Nucynta ER is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Nucynta ER with the following: alcohol, antihistamines (such as diphenhydramine), central nervous system (CNS) depressants (such as alprazolam, diazepam, or phenobarbital), certain antidepressants (such as fluoxetine, amitriptyline, mirtazapine, or trazodone), certain antipsychotic medications (such as haloperidol, olanzapine, or chlorpromazine), certain painkillers (such as buprenorphine, butorphanol, nalbuphine, or pentazocine), droperidol, other narcotic painkillers (such as oxycodone or tramadol), or MAOIs.

  • What are the possible side effects of Nucynta ER?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: breathing problems, confusion, constipation, dizziness, drowsiness, faintness, headache, low blood pressure, nausea, seizures, sleepiness

  • Can I receive Nucynta ER if I am pregnant or breastfeeding?

    The effects of Nucynta ER during pregnancy are unknown. Nucynta ER can harm your newborn baby if you use it during breastfeeding. Do not take Nucynta ER while you are breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Nucynta ER?

    If you miss a dose of Nucynta ER, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Nucynta ER?

    Store at room temperature. Protect from light.