What is Oforta?Oforta is a medicine used to treat B-cell chronic lymphocytic leukemia (CLL) in people whose disease has not responded to or has progressed during or after treatment with at least one standard treatment regimen.
What is the most important information I should know about Oforta?Oforta can cause life-threatening side effects on your nervous system. It can also affect your lungs, especially in combination with another anticancer medication called pentostatin. Tell your doctor immediately if you have problems seeing; feel very sleepy, tired, or confused; or have shortness of breath or trouble breathing.
Oforta can cause immune system problems, such as hemolytic anemia (a blood disorder in which red blood cells are destroyed). Tell your doctor immediately if you experience yellowing of your skin or whites of your eyes or dark urine. Oforta can also cause low platelet (type of blood cells that form clots to help stop bleeding) counts. Your doctor will monitor your blood cell counts before you start Oforta and regularly during your treatment. Tell your doctor if you experience bleeding or tiredness.
Oforta can cause a decrease in neutrophil counts in your blood (type of cell that fights infections). This may increase your risk of developing an infection. Tell your doctor if you experience a fever (100.5°F or greater), chills, cough, burning pain on urination, or other signs of an infection.
Oforta can cause tumor lysis syndrome, a life-threatening condition characterized by a rapid release of contents from tumor cells into your blood and causing metabolic problems, including abnormally high levels of uric acid in your blood.
Oforta can cause harm to your unborn baby if you take it during pregnancy. Tell your doctor immediately if you are pregnant or plan to become pregnant. If you are a man, use appropriate contraceptive measures while you are taking Oforta.
Who should not take Oforta?Do not take Oforta if you are allergic to it or any of its ingredients.
What should I tell my doctor before I take the first dose of Oforta?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Oforta. Also, talk to your doctor about your complete medical history, especially if you have kidney or bleeding problems, or are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Your doctor will prescribe the appropriate dose for you based on your weight and height.
If you have kidney impairment, your doctor will adjust your dose appropriately.
How should I take Oforta?Take Oforta exactly as prescribed by your doctor. You can take Oforta with or without food. Push the tablets through the foil to open. Do not remove the tablets from individual blisters until immediately before you take your scheduled dose. Swallow Oforta tablets whole with water; do not chew, crush, or break the tablets. If you cannot swallow the Oforta tablet whole, ask your doctor if you can take another form of fludarabine.
What should I avoid while taking Oforta?Do not let the Oforta tablets touch your skin. If you touch a broken tablet, wash the area thoroughly with soap and water.
Do not get any Oforta in your eyes. Wash your eyes immediately with water for at least 15 minutes and tell your doctor immediately if this occurs.
Do not chew, crush, or break the tablets or hold them in your mouth.
Do not breathe in any powder or residue from a broken tablet.
What are possible food and drug interactions associated with Oforta?If Oforta is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Oforta with pentostatin.
What are the possible side effects of Oforta?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: abdominal pain, cough, decreased blood cell counts, diarrhea, fever, headache, infections, irritation or redness in your mouth, loss of appetite, muscle pain, nausea, pain, skin rash, swelling of your legs, vomiting, weakness
Can I receive Oforta if I am pregnant or breastfeeding?Oforta can cause harm to your unborn baby if you take it during pregnancy. The effects of Oforta while breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Oforta?Oforta should be given under special circumstances determined by your doctor. If you miss your scheduled dose, contact your doctor for advice.
How should I store Oforta?Store at room temperature.