Omnitrope

Generic Name: Somatropin

  • What is Omnitrope?

    Omnitrope is used to treat children who are not growing because they are not producing enough growth hormone, have Prader-Willi Syndrome (PWS), were born small for gestational age (SGA), or have idiopathic short stature (ISS). This drug is also used in adults to treat growth hormone deficiency (GHD).

  • What is the most important information I should know about Omnitrope?

    Whether your doctor prescribes Omnitrope for injection or Omnitrope cartridge for use in a pen delivery system, you must read the instructions on the leaflet provided with your prescription. If you have additional questions or concerns, contact your doctor.

    Your blood sugar levels will be monitored regularly, especially if you are at risk for diabetes such as having obesity, Turner Syndrome, or a family history of diabetes. The doses of your diabetes medications may have to be adjusted.

    You may experience an increase in the pressure within the skull. Symptoms include papilledema (swelling of the optic nerve), changes in your vision, headache, nausea, and vomiting. Your doctor will regularly check your eyes for papilledema. If it is present, Omnitrope should be stopped.

    Fluid accumulation may occur with Omnitrope treatment in adults.

    If you have low thyroid hormone levels or an underactive thyroid gland that is not treated, you may not respond to Omnitrope as well. Your doctor will check your thyroid function and, if necessary, start or change your thyroid hormone replacement therapy.

    If children develop a limp or hip or knee pain, immediately tell the doctor.

    If you were previously treated with somatropin (the active ingredient in Omnitrope) replacement therapy as a child, your doctor will reevaluate you before continuing therapy at the reduced dose level recommended for GHD in adults.

    Allergic reactions may occur; seek immediate medical attention.

  • Who should not take Omnitrope?

    Omnitrope should not be taken if you are allergic to its ingredients. Do not begin therapy with Omnitrope if you are have cancer which has not been treated. Omnitrope should not be used in children whose bones are completely fused. This drug should not be taken if you are critically ill due to complications following open heart or abdominal surgery, multiple accidental traumas, or respiratory failure. Omnitrope should not be used in people with PWS who are severely obese, have airway obstruction, or have respiratory problems. It should also not be used in patients who have diabetic retinopathy, an eye disease in people with high blood sugar. Certain formulations of Omnitrope contain benzyl alcohol and should not be used in premature babies or newborns.

  • What should I tell my doctor before I take the first dose of Omnitrope?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Omnitrope. Also, talk to your doctor about your complete medical history, especially if you have complications from open heart or abdominal surgery, multiple accidental traumas, or acute respiratory failure; have PWS and are obese or have airway obstruction or infection; have been receiving treatment for any type of cancer/tumor; have diabetes or thyroid problems; have multiple pituitary hormone deficiencies; have scoliosis; or were treated with somatropin replacement therapy as a child.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Growth Hormone Deficiency
    Adults: The recommended starting dose is not more than 0.04 milligrams (mg) per 2.2 pounds of body weight a week. The dosage may be increased at 4- to 8-week intervals to a maximum of 0.08 mg per 2.2 pounds of body weight a week. However, your doctor may use an alternative dosage. Lower doses and smaller increment increases should be considered for older patients.

    Children: The usual dose is 0.16 to 0.24 mg per 2.2 pounds of body weight a week.

    Prader-Willi Syndrome
    Children: The usual dose is 0.24 mg per 2.2 pounds of body weight a week.

    Small for Gestational Age
    Children: The usual dose is 0.48 mg per 2.2 pounds of body weight a week.

    Idiopathic Short Stature
    Children: The usual dose is 0.47 mg per 2.2 pounds of body weight a week.

  • How should I take Omnitrope?

    The weekly dose should be divided into six or seven doses, injected under the skin in the evening. Omnitrope may be given in the thigh, buttocks, or stomach; always rotate the site of injection.

    Those administering Omnitrope should receive appropriate training on its proper use from a physician or qualified health professional.

  • What should I avoid while taking Omnitrope?

    Never share the Omnitrope pen with another person, even if the needle is changed. The pen needle is sterile; avoid contaminating the needle after opening it. Do not place it on a surface or touch exposed parts.

    Avoid storing or carrying your Omnitrope with a pen needle attached. Never recap the pen with the pen needle on.

  • What are possible food and drug interactions associated with Omnitrope?

    If Omnitrope is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is important to check with your doctor before combining Omnitrope with any of the following: anticonvulsants, corticosteroids/glucocorticoids such as prednisone, cyclosporine, diabetes medications, estrogens, insulin, or sex steroids.

  • What are the possible side effects of Omnitrope?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: injection site reactions (such as pain, redness), joint pain, muscle pain, stiffness of the hands and feet, swelling, numbness, increased blood sugar, hematoma (swelling filled with blood), headache, leg pain

  • Can I receive Omnitrope if I am pregnant or breastfeeding?

    The effects of Omnitrope during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Omnitrope?

    If you miss your scheduled dose, it is best to speak to your healthcare provider for advice.

  • How should I store Omnitrope?

    Store in a refrigerator away from light and in the carton; do not freeze.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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