What is this medication and its most common uses?Onfi is a medicine used along with other medicines to treat seizures associated with Lennox-Gastaut syndrome (LGS). Onfi is available as tablets and an oral suspension.
Onfi is a federally controlled substance because it has abuse potential.
What should I know when beginning and continuing on this medication?How does this medication work?
Onfi works by slowing down your brain activity, thereby producing a calming effect.
What are the beneficial effects of this medication and when should I begin to have results?
What: When used with your current seizure medicine(s), Onfi has been shown to lower the number of weekly seizures you may experience.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Onfi exactly as your healthcare provider has prescribed.
How do I know it is working?
You may start to notice a reduction in the number of seizures you normally experience. This is a good indicator that your medication is working. Your healthcare provider will ask you questions from time to time to assess how well your seizures are controlled. Having a record or seizure diary to keep track of when you experienced a seizure (date and under what circumstances) will be helpful to you and your healthcare provider in monitoring your progress.
What are the possible side effects of this medication?The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: constipation, drowsiness, sleepiness, fever, tiredness, drooling.
Less common side effects may include:
Mental and physical dependence can occur. Keep Onfi in a safe place to prevent misuse and abuse.
Seizures can occur if you stop taking Onfi or decrease your dose. Do not stop taking Onfi or change the dose without first talking to your healthcare provider.
Serious allergic reactions, with symptoms such as hives or rash.
Suicidal thoughts or actions, with symptoms such as thoughts about suicide or dying; attempts to commit suicide; new or worse depression, anxiety, or irritability; feeling agitated or restless; trouble sleeping; panic attacks; acting aggressive, being angry, or violent; acting on dangerous impulses; an extreme increase in activity and talking; or other unusual changes in your behavior or mood.
Who should not take this medication?Do not take Onfi if you are allergic to it or any of its ingredients.
What should I tell my healthcare provider before I take the first dose of this medication?Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Onfi. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney, liver, or lung problems; have or have had depression, mood problems, or suicidal thoughts or behaviors; take birth control pills; or if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults and children ≥2 years: Your healthcare provider will prescribe the appropriate dose for you or your child based on the weight.
Your healthcare provider may increase your or your child's dose as needed, until the desired effect is achieved.
If you are elderly or have kidney impairment, your healthcare provider may adjust your dose appropriately.
It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.
How should I take this medication?Take Onfi exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Onfi without first talking to your healthcare provider.
Take Onfi with or without food.
Take Onfi tablets whole, broken in half along the score, or crushed and mixed in applesauce.
Shake the bottle of Onfi oral suspension well right before you take each dose.
Please review the instructions that came with your prescription on how to properly take Onfi oral suspension.
What should I avoid while taking this medication?Do not drive a car, operate machinery, or engage in other dangerous activities until you know how Onfi affects you.
Do not drink alcohol or take other medicines that may make you dizzy or sleepy while you are taking Onfi.
What are the possible food and drug interactions associated with this medication?If Onfi is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Onfi with the following: alcohol, birth control pills, dextromethorphan, fluconazole, fluvoxamine, omeprazole, other medicines that may make you sleepy (such as oxycodone or diphenhydramine), or ticlopidine.
May I receive this medication if I am pregnant or breastfeeding?The effects of Onfi during pregnancy are unknown. Onfi can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you become pregnant while taking Onfi, talk to your healthcare provider about registering with the North American Antiepileptic Drug (NAAED) Pregnancy Registry. The purpose of this registry is to collect information about the safety of the seizure medicine during pregnancy.
What should I do if I miss a dose of this medication?If you miss a dose of Onfi, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store this medication?Store at room temperature. Store Onfi oral suspension in an upright position.