Generic Name: Saxagliptin

  • What is Onglyza?

    Onglyza is a medicine that is used with diet and exercise to control high blood sugar in adults with type 2 diabetes by helping the body increase the level of insulin after meals.

  • What is the most important information I should know about Onglyza?

    If you experience periods of stress on the body, such as fever, trauma, infection, or surgery, contact your doctor right away, as your medication needs may change.

    It is important to adhere to dietary instructions and regular physical activity while taking Onglyza. It is also important to periodically monitor your blood sugar levels and have A1C testing. This is to monitor how well you are responding to treatment.

    You should be aware of the symptoms of low blood sugar (hypoglycemia). Symptoms include shaking, sweating, rapid heartbeat, vision changes, hunger, headache, and mood changes. The risk of hypoglycemia may be greater if you are taking other diabetes medications, such as glyburide.

  • Who should not take Onglyza?

    Patients who have type 1 diabetes or diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin) should not take Onglyza.

  • What should I tell my doctor before I take the first dose of Onglyza?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Onglyza. Also, talk to your doctor about your complete medical history, especially if you have a history or risk of diabetic ketoacidosis, kidney problems, or type 1 diabetes.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is 2.5 milligrams (mg) or 5 mg once a day. Your doctor may prescribe 2.5 mg once a day if you have kidney disease.

  • How should I take Onglyza?

    Take Onglyza exactly as prescribed. Onglyza can be taken with or without food.

  • What should I avoid while taking Onglyza?

    Do not change the dose of Onglyza without talking to your doctor.

  • What are possible food and drug interactions associated with Onglyza?

    If Onglyza is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Onglyza with the following: atazanavir, clarithromycin, other diabetes medications called sulfonylureas (such as glimepiride, glipizide, glyburide) or thiazolidinediones (such as pioglitazone), indinavir, insulin, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin.

  • What are the possible side effects of Onglyza?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: upper respiratory tract infection, urinary tract infection, headache, low blood sugar, swelling or fluid retention of extremities, allergic reactions

  • Can I receive Onglyza if I am pregnant or breastfeeding?

    The effects of Onglyza during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Onglyza?

    If you miss a dose of Onglyza, take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Onglyza?

    Store at room temperature.

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