Generic Name: Pioglitazone

  • What is this medication and its most common uses?

    Oseni is a medicine used along with diet and exercise to help control high blood sugar in adults with type 2 diabetes. Oseni contains two medicines that work in two different ways to lower your blood sugar levels: alogliptin and pioglitazone.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Alogliptin helps your body release more insulin. Pioglitazone helps your body respond better to the insulin it makes naturally. Together, they help to control your blood sugar.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Lowering your blood sugar to a normal level may prevent or delay potential complications associated with diabetes, such as blindness, kidney failure, or heart problems. Also, the combination of medicines in Oseni provides better control of blood sugar compared to either alogliptin or pioglitazone alone.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Oseni exactly as your healthcare provider has prescribed.

    How do I know it is working?

    Check your blood sugar regularly and as your healthcare provider tells you to. Your healthcare provider will also do regular blood tests to measure your blood sugar levels and your hemoglobin A1C (measures your average blood sugar levels over a 2- to 3-month period). Stay on your prescribed diet and exercise program, as this will also affect the results of your blood tests.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Oseni can cause your body to retain extra fluid, which leads to swelling and weight gain. Extra body fluid can make some heart problems worse or lead to heart failure. Call your healthcare provider right away if you experience swelling or fluid retention, especially in your ankles or legs; shortness of breath or trouble breathing, especially when you lie down; unusually fast increase in your weight; or unusual tiredness.

    More common side effects may include: stuffy or runny nose and sore throat, back pain, upper respiratory infection.

    Less common side effects may include:

    Pancreatitis (inflammation of the pancreas) with symptoms such as pain in your abdomen (stomach area) that is severe and will not go away. You may feel the pain going from your abdomen through to your back and may experience vomiting.

    Serious allergic reactions with symptoms such as rash; hives; and swelling of your face, lips, tongue, or throat that may cause trouble breathing.

    Liver problems, with symptoms such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, or yellowing of your skin or the whites of your eyes.

    Bone fractures, usually in the hand, upper arm, or foot.

    Increased risk of bladder cancer with symptoms such as blood or a red color in your urine, an increased need to urinate, or pain while you urinate.

    Low blood sugar with symptoms such as shaking, sweating, rapid heartbeat, changes in your vision, hunger, headache, or changes in your mood. Your risk of low blood sugar is higher if you do not eat enough, drink alcohol, or take other medicines to lower your blood sugar.

    Macular edema (swelling in the back of the eye) with changes in your vision.

    Ovulation (release of an egg from an ovary in a woman) leading to pregnancy.

  • Who should not take this medication?

    Do not take Oseni if you are allergic to it or any of its ingredients.

    Do not take Oseni if you have severe heart failure.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Oseni. Also, talk to your healthcare provider about your complete medical history, especially if you have pancreatitis; gallstones (stones in your gallbladder); a history of alcoholism; kidney, liver, or heart problems; macular edema; bladder cancer; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous diabetes medication, and may adjust your dose as needed, until the desired effect is achieved.

    If you have kidney impairment, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take Oseni exactly as prescribed by your healthcare provider.

    Take Oseni once a day, with or without food.

    Swallow Oseni tablets whole. Do not break or cut the tablets before swallowing.

    If your body is under some types of stress (such as a fever, infection, trauma [such as a car accident], or surgery), your healthcare provider may need to adjust the dose of your diabetes medicine.

    While you are taking Oseni, stay on your diet and exercise program, and check your blood sugar regularly as directed by your healthcare provider.

  • What should I avoid while taking this medication?

    Do not change your dose or stop taking Oseni without first talking to your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If Oseni is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Oseni with the following: gemfibrozil or rifampin.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of Oseni during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Oseni. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Oseni, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from moisture and humidity.