Paxil CR

Generic Name: Paroxetine hydrochloride, controlled-release

  • What is Paxil CR?

    Paxil CR is used to treat depression, panic disorder, social anxiety disorder, and premenstrual dysphoric disorder.
  • What is the most important information I should know about Paxil CR?

    Paxil CR is not approved for use in pediatric patients.

    Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults when the medicine is first started. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar disorder (also called manic-depressive illness) or suicidal thoughts or actions.

    Pay close attention to any changes, especially sudden ones, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is first started or when the dose is changed.

    Call the doctor right away to report new or sudden changes in mood, behavior, thoughts, or feelings. Signs to watch for include new or worsening depression, new or worsening anxiety, agitation, insomnia, hostility, panic attacks, restlessness, extreme hyperactivity, and suicidal thinking or behavior.

    Keep all follow-up visits as scheduled, and call the doctor between visits as needed, especially if you have concerns about symptoms.

    Paxil CR is not approved for use in pediatric patients.

  • Who should not take Paxil CR?

    You should not take Paxil CR if you are allergic to it or any of its components. It should also be avoided if you are currently taking monoamine oxidase inhibitors (MAOIs), linezolid, thioridazine, or pimozide.
  • What should I tell my doctor before I take the first dose of Paxil CR?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Paxil CR. Also, talk to your doctor about your complete medical history, especially if you intend on becoming pregnant or if you have a history of suicidal thoughts, panic attacks, insomnia, seizures, glaucoma, or severe kidney or liver impairment.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Depression

    Adults: The recommended starting dose is 25 milligrams (mg) daily. Depending on how you respond to Paxil CR, your doses may be increased in 12.5 mg/day increments up to a maximum daily dose of 62.5 mg.

    Panic Disorder

    Adults: The recommended starting dose is 12.5 mg daily. Depending on how you respond to Paxil CR, your doses may be increased in 12.5 mg/day increments up to a maximum daily dose of 75 mg.

    Social Anxiety Disorder

    Adults: The recommended starting dose is 12.5 mg daily. Depending on how you respond to Paxil CR, your doses may be increased in 12.5 mg/day increments up to a maximum daily dose of 37.5 mg.

    Premenstrual Dysphoric Disorder

    Adults: The recommended starting dose is 12.5 mg daily. Depending on how you respond to Paxil CR, your dose may be increased 25 mg daily.

  • How should I take Paxil CR?

    Paxil CR is taken once daily, usually in the morning, with or without food. Swallow the tablets whole, and never chew or crush them.
  • What should I avoid while taking Paxil CR?

    Avoid drinking alcohol during treatment with Paxil CR. Avoid driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness until you know how this drug affects you.
  • What are possible food and drug interactions associated with Paxil CR?

    If Paxil CR is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Paxil CR with the following: almotriptan, clorgyline, dexfenfluramine, dextromethorphan, droperidol, eletriptan, fenfluramine, frovatriptan, furazolidone, isoniazid, isocarboxazid, linezolid, moclobemide, naratriptan, nefazodone, nialamide, pargyline, phenelzine, pimozide, procarbazine, rasagiline, rizatriptan, selegiline, sibutramine, St. John's wort, sumatriptan, thioridazine, toloxatone, tramadol, tranylcypromine, trazodone, tryptophan, and zolmitriptan.
  • What are the possible side effects of Paxil CR?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: somnolence, insomnia, nausea, asthenia, abnormal ejaculation, dry mouth, constipation, dizziness, diarrhea, decreased libido, sweating, female genital disorders, tremor

  • Can I receive Paxil CR if I am pregnant or breastfeeding?

    For women who intend to become pregnant or are in their first trimester of pregnancy, Paxil CR should only be initiated after consideration of the other available treatment options. The effects of Paxil CR during breastfeeding are unknown; discuss your options with your doctor.
  • What should I do if I miss a dose of Paxil CR?

    Skip the missed dose and go back to your regular schedule. Do not take a double dose to make up for the one you missed.
  • How should I store Paxil CR?

    Store at room temperature.