Generic Name: Prednisolone

  • What is Pediapred?

    Pediapred, a steroid drug, is used to reduce inflammation and improve symptoms in a variety of disorders, including rheumatoid arthritis, acute gouty arthritis, primary or secondary adrenal cortex insufficiency, and severe cases of asthma. It is also given to help treat the following disorders: blood disorders such as leukemia and various anemias, certain cancers (along with other drugs), connective tissue diseases such as systemic lupus erythematosus, digestive tract diseases such as ulcerative colitis, eye diseases of various kinds, fluid retention due to nephrotic syndrome (a condition in which damage to the kidneys causes a loss of protein in the urine), high blood levels of calcium associated with cancer, lung diseases such as tuberculosis, severe allergic conditions such as drug-induced allergic reactions, and severe skin eruptions. Studies have shown that high doses of Pediapred are effective in controlling severe symptoms of multiple sclerosis, although they do not affect the ultimate outcome or natural history of the disease.

  • What is the most important information I should know about Pediapred?

    Do not stop your course of Pediapred treatment abruptly.

    Pediapred decreases your resistance to infection. It may also mask some of the signs and symptoms of an infection, which makes it difficult for a doctor to diagnose the actual problem.

    If you should develop a fever or other signs of infection while taking Pediapred, notify your doctor immediately.

    Avoid exposure to chickenpox and measles. If you are exposed, seek medical advice without delay.

    While being treated with Pediapred, live vaccines should not be given, as this drug may suppress your immune system. Killed or inactivated vaccines can be administered, but the body's response cannot be predicted.

  • Who should not take Pediapred?

    This drug should not be used for fungal infections within the body. Avoid it if it gives you an allergic reaction.

  • What should I tell my doctor before I take the first dose of Pediapred?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with this drug. Also, talk to your doctor about your complete medical history. Your doctor will prescribe this medication very cautiously if you have any of the following: ulcerative colitis (inflammation of the colon and rectum) where there is a possibility of a puncture, abscess, or other infection; diverticulitis (inflammation of a sac formed at weak points of the colon); recent intestinal anastomoses (a surgical connection between two separate parts of the colon); active or inactive peptic (stomach) ulcers; unsatisfactory kidney function; congestive heart failure; high blood pressure; osteoporosis (brittle bones that may fracture); eye problems; myasthenia gravis (a long-term disease characterized by abnormal fatigue and weakness of certain muscles); if you are going through menopause; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The starting dosage of Pediapred may vary from 5 milliliters (mL) to 60 mL (5-60 milligrams [mg]), depending on the specific disease being treated.

    Children: The starting dosage ranges from 0.14 to 2 mg per 2.2 pounds of body weight per day, divided into 3 or 4 smaller doses.

    Acute Flare-ups of Multiple Sclerosis
    The usual dose is 200 mg per day of Pediapred for 1 week followed by 80 mg every other day for 1 month.

    Asthma Uncontrolled by an Inhaler
    The recommended dosage is 1-2 mg per 2.2 pounds of body weight per day, taken as a single or several smaller doses.

    Nephrotic Syndrome
    The recommended dosage is 60 mg/m2/day given in 3 divided doses for 4 weeks, followed by 4 weeks of single dose alternate-day therapy at 40 mg/m2/day.

  • How should I take Pediapred?

    Pediapred may cause stomach upset and should be taken with food. Take this medication exactly as prescribed.

    Measure the liquid with a special dose-measuring spoon or cup, not a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist for one.

  • What should I avoid while taking Pediapred?

    Do not discontinue the use of Pediapred abruptly or without medical supervision.

    You should not be vaccinated against smallpox while being treated with Pediapred. Avoid other immunizations as well, especially if you are taking Pediapred in high doses, because of the possible hazards of nervous system complications and a lack of natural immune response.

    Because Pediapred reduces resistance to infection, people who have never had measles or chickenpox (or been vaccinated against them) should be careful to avoid exposure. These diseases can be severe, or even fatal, in people with lowered resistance. Likewise, an ordinary case of threadworm or other intestinal parasites can grow into a grave emergency when the immune system is weak. Symptoms of threadworm include stomach pain, vomiting, and diarrhea. If you suspect an infection, call your doctor immediately.

  • What are possible food and drug interactions associated with Pediapred?

    If Pediapred is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Pediapred with the following: amphotericin B, anticholinesterase agents, aspirin, barbiturates such as phenobarbital and secobarbital, cyclosporine, diabetes drugs such as glipizide, diuretics, ephedrine, estrogens, isoniazid, ketoconazole, nonsteroidal anti-inflammatory drugs such as ibuprofen, oral contraceptives, phenytoin, rifampin, vaccines, and warfarin.

  • What are the possible side effects of Pediapred?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: allergic reactions, headache, hot flashes, increased appetite, nausea/stomach upset, rash, stomach/intestinal pain, sweating, swelling, tiredness

  • Can I receive Pediapred if I am pregnant or breastfeeding?

    The effects of Pediapred during pregnancy are unknown. If you are pregnant or plan to become pregnant, inform your doctor immediately.

    This medication may appear in breast milk and could affect a nursing infant. If this drug is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

  • What should I do if I miss a dose of Pediapred?

    Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular dosing schedule. Never take two doses at the same time.

  • How should I store Pediapred?

    Store in a cool place. Keep the bottle tightly closed. This medication may be refrigerated.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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