Pentacel

Generic Name: Diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus vaccine and Haemophilus b conjugate (tetanus toxoid conjugate) vaccine

  • What is Pentacel?

    Pentacel is a five-in-one combination vaccine intended to prevent diphtheria, tetanus, pertussis (whooping cough), polio, and Haemophilus b infection. It is used in children 6 weeks through 4 years of age (prior to the fifth birthday).
  • What is the most important information I should know about Pentacel?

    Pentacel should not be given to anyone with history of allergic reactions to any vaccine that protects against diphtheria, tetanus, pertussis, H. influenzae, or polio.

    Pentacel should not be given to anyone who experienced a brain or nervous system disorder within 7 days of receiving pertussis-containing vaccine; who had Guillain-Barré syndrome after receiving a vaccine containing tetanus toxoid; or who had any of the following problems within 48 hours after a dose of pertussis-containing vaccine: fever ≥105°F, shock-like state, persistent crying lasting 3 hours or more, seizures with or without fever within 3 days of vaccination.

    Pentacel is a vaccine and, as with other vaccines, there is a risk of allergic reaction. Signs of severe allergic reactions may include hives, difficulty breathing, and swelling of the throat. If any of these events occur, seek immediate medical attention.

  • Who should not take Pentacel?

    See "What is the most important information I should know about this Pentacel?" above.

    Additionally, Pentacel should not be given to children with progressive neurological damage; children who experienced encephalopathy (eg, coma, decreased level of consciousness, or prolonged seizures) within 7 days of a previous dose of pertussis-containing vaccine; or children <6 weeks of age or ≥5 years of age.

  • What should I tell my doctor before I take the first dose of Pentacel?

    Tell your doctor about all vaccines and prescription, over-the-counter and herbal medications your child has received before beginning treatment with Pentacel. Also talk to your doctor about your child's complete medical history, especially if they have a history of seizures, a weakened immune system, or a history of allergic reactions to vaccines or latex.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Children ≥6 weeks to <5 years: Pentacel is administered as a single intramuscular injection.

  • How should I take Pentacel?

    Pentacel will be injected by the nurse or doctor in the upper leg (thigh), upper arm, or buttocks.
  • What should I avoid while taking Pentacel?

    There are no specific warnings regarding activities to avoid after receiving this vaccination.
  • What are possible food and drug interactions associated with Pentacel?

    If Pentacel is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Pentacel with corticosteroids, cytotoxic drugs, and immunosuppressive therapies, including irradiation
  • What are the possible side effects of Pentacel?

    As with any other vaccine, there is a risk of allergic reactions. Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible.

    Side effects may include: pain, redness, or swelling at the injection site, fever, inconsolable crying, decreased activity, lethargy, irritability.

    Signs of severe allergic reactions may include hives, difficulty breathing, and swelling of the throat. If any of these events occur, seek immediate medical attention.

  • Can I receive Pentacel if I am pregnant or breastfeeding?

    The effects of Pentacel during pregnancy and breastfeeding are unknown. Pentacel is to be avoided in women of child bearing age.
  • What should I do if I miss a dose of Pentacel?

    This is a one-time vaccine administered in your doctor's office.
  • How should I store Pentacel?

    Pentacel will be administered in your doctor's office.