Generic Name: Oxycodone

  • What is Percodan?

    Percodan is a combination of two pain-killing drugs--oxycodone and aspirin and is used for moderate to moderately severe pain.

  • What is the most important information I should know about Percodan?

    The oxycodone in Percodan can cause physical and psychological dependence. Use this product with caution. Never take more Percodan than is prescribed for you because this may heighten your risk of serious breathing problems. If your pain is not being adequately treated, talk to your doctor.

    Do not stop taking Percodan suddenly if you have been taking it continuously for more than 5-7 days. Stopping suddenly could cause withdrawal symptoms and make you very uncomfortable. Your doctor may want to gradually reduce your dose.

    Tell your doctor or dentist that you take Percodan before you receive any medical or dental care, emergency care, or surgery.

    Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (e.g., sleep aids, muscle relaxers) while you are using Percodan; it may add to their effects.

    Percodan may cause stomach bleeding. Your risk may be greater if you drink alcohol while you are using Percodan.

    Percodan may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

  • Who should not take Percodan?

    Do not take Percodan if you are allergic to either aspirin or oxycodone. Also, Percodan cannot be used in situations where opioids cannot be used, such as severe asthma or during an asthma attack, with nasal swelling, high levels of carbon dioxide in the blood, or if you have blockage of your bowel or other stomach or bowel problems.

    In children and teenagers who have a viral infection, the aspirin in Percodan can trigger a severe, and even fatal, disorder called Reye's syndrome. Do not give Percodan to any child with an illness such as flu or chickenpox.

  • What should I tell my doctor before I take the first dose of Percodan?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Percodan. Also, talk to your doctor about your complete medical history, especially if you have: a clotting disorder, a head injury, a thyroid condition, abdominal disorders, Addison's disease, an enlarged prostate, difficulty urinating, kidney problems, seizures, a history of lung or breathing problems such as asthma, emphysema, or bronchitis, heart problems, low blood pressure, a history of alcohol or substance abuse or dependence or if you drink alcohol regularly (more than three alcohol beverages a day), a history of mental or mood problems, suicidal thoughts, or suicide attempts, liver problems, or peptic ulcer disease. Also, tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose is one tablet every 6 hours as needed for pain. Your doctor may adjust the dosage according to the severity of pain and your response to the drug. The maximum daily dose of aspirin should not exceed 4 grams, or 12 tablets. When stopping treatment with Percodan, after at least a few weeks of therapy, dosage should be gradually reduced to prevent symptoms of withdrawal.

    Children: A special formulation of Percodan called Percodan Demi is available for children. Do not give full-strength Percodan to a child.

  • How should I take Percodan?

    Take Percodan exactly as your doctor instructs. Never take more of this medication than is prescribed for you. Do not stop taking Percodan or change your dose without first contacting your doctor.

    The oxycodone in Percodan may also cause constipation. Drink plenty of water (six to eight full glasses a day) to lessen this side effect. Increasing the amount of fiber in your diet can also help to alleviate constipation.

    Take Percodan with food or milk if it upsets your stomach.

  • What should I avoid while taking Percodan?

    Percodan can impair the skills you need to drive a car or operate machinery safely. Do not attempt to drive if you are not fully alert or until you know how you react to this medication.

    Avoid alcohol while taking Percodan. Alcohol may increase the drowsiness and dizziness caused by Percodan and could be dangerous. Also, alcohol increases the risk of stomach bleeding when you are taking a medication that contains aspirin.

    Do not give Percodan to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.

    Avoid activities that may cause bruising or injury.

    Avoid sitting up or standing quickly, especially in the morning.

  • What are possible food and drug interactions associated with Percodan?

    If Percodan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Percodan with the following: ACE inhibitors, acetazolamide, alcohol, alprazolam, antidepressants, anticoagulants, antidiabetes drugs, beta-blockers, blood-thinners, chlorpromazine, diazepam, diuretics, probenecid, prochlorperazine, methotrexate, NSAIDs, other narcotic pain killers, sleep aids such as secobarbital, triazolam, trifluoperazine.

  • What are the possible side effects of Percodan?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: constipation, dizziness, exaggerated feelings of well-being or sadness, itching, lightheadedness, nausea, sedation, vomiting, drowsiness, stomach upset, bloody or black stools, dark urine, decreased urination, muscle pain, fever, chills, persistent sore throat, hoarseness, severe or persistent heartburn, trouble swallowing

  • Can I receive Percodan if I am pregnant or breastfeeding?

    Can I receive this medication if I am pregnant or breastfeeding? Percodan is not recommended for pregnant women under ordinary circumstances. Inform your doctor immediately if you become pregnant. Also, consult your doctor before using Percodan while breastfeeding. Percodan has been shown to cause harm to the fetus, avoid using Percodan in the last 3 months of pregnancy.

  • What should I do if I miss a dose of Percodan?

    Since Percodan is sometimes used as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not take two doses at once.

  • How should I store Percodan?

    Store Percodan at room temperature away from heat, moisture, and light.

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I'm Kristen Dore, PharmD. Welcome to PDR Health!

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