• What is Perphenazine?

    Perphenazine is indicated for use in the treatment of schizophrenia and for the control of severe nausea and vomiting in adults.
  • What is the most important information I should know about Perphenazine?

    Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary movements, may develop in patients treated with antipsychotic drugs. Older patients are at an increased risk. There is no known treatment for established cases of tardive dyskinesia.

    A potentially fatal symptom complex referred to as neuroleptic malignant syndrome (NMS) has been reported in association with antipsychotic drugs. Signs and symptoms of NMS include muscle rigidity, confusion, irregular pulse or blood pressure, etc. Contact your doctor immediately if you experience any of these symptoms.

    Perphenazine may impair the mental and/or physical abilities required for the performance of hazardous tasks such as driving a car or operating machinery.

    Perphenazine is not for use in children under 12 years of age.

  • Who should not take Perphenazine?

    Patients who have previously had a severe reaction to other phenothiazines should not take perphenazine.

    Perphenazine should be used with caution in patients with depression.

    Patients who have decreased kidney function should speak with their physician before taking perphenazine.

  • What should I tell my doctor before I take the first dose of Perphenazine?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with perphenazine. Also talk to your doctor about your complete medical history, especially past or current kidney problems, respiratory problems, or a history of suicidality. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Dosage of perphenazine must be individualized and adjusted according to the severity of the condition and the response obtained. As with all drugs, the best dose is the lowest dose that will produce the desired effect.


    Adults: 4 to 8 milligrams (mg) three times daily initially; the doctor will reduce this dose as soon as possible to the minimum effective dose.

    Severe Nausea and Vomiting

    Adults: 8 to 16 mg daily in divided doses; up to 24 mg may occasionally be necessary.

  • How should I take Perphenazine?

    Take perphenazine as directed by your physician.
  • What should I avoid while taking Perphenazine?

    Avoid alcohol since additive effects and decreased blood pressure may occur.

    Use caution in extreme heat. Avoid excessive exposure to the sun.

    Do not expose yourself to phosphorous insecticides.

  • What are possible food and drug interactions associated with Perphenazine?

    If perphenazine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining perphenazine with the following: antihistamines, analgesics, barbiturates, opiates, SSRIs (such as fluoxetine, sertraline, and paroxetine), and tricyclic antidepressants.
  • What are the possible side effects of Perphenazine?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: drowsiness, yellowing of the skin and eyes (jaundice), movement disorders, aching and numbness of the limbs, slurred speech, seizures, headaches, insomnia, bizarre dreams, dry mouth, nasal congestion, fluctuations in blood pressure

  • Can I receive Perphenazine if I am pregnant or breastfeeding?

    Safe use of perphenazine during pregnancy and breastfeeding has not been established. Consult your doctor before becoming pregnant while taking perphenazine.
  • What should I do if I miss a dose of Perphenazine?

    If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your normal dosage schedule.
  • How should I store Perphenazine?

    Store at room temperature, away from heat, light, and moisture.