Generic Name: Dipyridamole

  • What is this medication and its most common uses?

    Persantine is a medicine used in combination with blood thinners (such as warfarin) to prevent the formation of blood clots in people who have had heart valve replacement surgery.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Blood clots form when certain blood cells, called platelets, clump together. Persantine works by making platelets in the blood less sticky, so they are less likely to clump together and form blood clots.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Studies have shown that Persantine in combination with warfarin decreased the development of blood clots after surgery by 62% to 91% compared to treatment with warfarin alone.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Persantine exactly as your healthcare provider has prescribed.

    How do I know it is working?

    Your healthcare provider will monitor you regularly to check how well this medication is working.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: dizziness.

    Less common side effects may include:

    New or worsening chest pain in some people with heart disease.

    Liver problems, with symptoms such as loss of appetite, pale colored stool, abdominal pain, yellowing of your skin or the whites of your eyes, dark urine, or itching.

  • Who should not take this medication?

    Do not take Persantine if you are allergic it or any of its ingredients.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Persantine. Also, talk to your healthcare provider about your complete medical history, especially if you have heart or liver problems, low blood pressure, myasthenia gravis (a disease characterized by long-lasting fatigue and muscle weakness), a history of bleeding problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The recommended dose is 75-100 milligrams 4 times a day.

  • How should I take this medication?

    Take Persantine exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Persantine without first talking to your healthcare provider.

  • What should I avoid while taking this medication?

    Do not take aspirin in combination with blood thinners.

  • What are the possible food and drug interactions associated with this medication?

    If Persantine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Persantine with the following: adenosine or medicines used for Alzheimer's disease (such as donepezil or rivastigmine).

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of Persantine during pregnancy are unknown. Persantine can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Persantine, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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