Phospholine Iodide

Generic Name: Echothiophate iodide

  • What is Phospholine Iodide?

    Phospholine Iodide is used to treat chronic open-angle glaucoma, a partial loss of vision or blindness resulting from a gradual increase in pressure of fluid in the eye. Because the vision loss occurs slowly, people often do not experience any symptoms and do not realize that their vision has declined. By the time the loss is noticed, it may be irreversible. Phospholine Iodide helps by reducing fluid pressure in the eye.

    Phospholine Iodide is also used to treat secondary glaucoma (such as glaucoma following surgery to remove cataracts); subacute or chronic angle-closure glaucoma after iridectomy (surgical removal of a portion of the iris); or when someone cannot have surgery or refuses it. This drug is also prescribed for children with accommodative esotropia (cross-eye).

  • What is the most important information I should know about Phospholine Iodide?

    Avoid exposure to certain pesticides or insecticides such as Sevin and Trolene. They can boost the side effects of Phospholine Iodide. If you work with these chemicals, wear a mask over your nose and mouth, wash and change your clothing frequently, and wash your hands often.

    Contact your doctor immediately if you notice any decrease in vision or an increase in floaters in your visual field. Rarely, Phospholine Iodide may cause retinal detachment. Retinal detachment can lead to blind spots, floaters in your visual field, and even blindness. Your doctor will want to check your retina before you use this medicine to determine if you have an increased risk or a prior history of retinal detachment.

    Stop taking the drug and notify your doctor immediately if you experience any of the following: breathing difficulties, diarrhea, inability to hold urine, muscle weakness, profuse sweating, or salivation. If you will be using Phospholine Iodide for a long time, your doctor should schedule regular examinations to make sure that Phospholine Iodide is not causing unwanted effects.

    Phospholine Iodide Eye Drops is for use in the eye only. Do not get Phospholine Iodide Eye Drops in your nose or mouth.

    Use caution when driving, operating machinery, or performing other hazardous activities. Phospholine Iodide may cause your vision to decrease at night. If you experience decreased vision, avoid these activities.

    If you wear contact lenses, remove them before applying Phospholine Iodide ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Do not use other eye medications during treatment with Phospholine Iodide, except under the direction of your doctor.

    Phospholine Iodide eye drops may be stored in room temperature for up to four weeks.

    See "How do I take this medication?" for proper procedures on how to prepare and apply Phospholine Iodide.

  • Who should not take Phospholine Iodide?

    You should not use Phospholine Iodide if you have an inflammation in the eye.

    Most people with angle-closure glaucoma (a condition in which there is a sudden increase in pressure of fluid in the eye) should not use Phospholine Iodide due to the possibility of increasing angle block. This condition is also known as narrow-angle glaucoma.

    If you have ever had an allergic reaction to or are sensitive to Phospholine Iodide or any of its ingredients, you should not use Phospholine Iodide.

  • What should I tell my doctor before I take the first dose of Phospholine Iodide?

    Tell your doctor about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with Phospholine Iodide. Also, talk to your doctor about your complete medical history, especially if you have had heart failure; high or low blood pressure; a heart attack; asthma; certain nerve problems; a stomach ulcer or stomach spasms; epilepsy; hyperthyroidism (an overactive thyroid); blockage of the urinary tract or difficulty urinating; or Parkinson's disease.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Glaucoma

    Adults: A dose of 0.03 percent should be used 2 times a day, in the morning and at bedtime. Your doctor may increase the dose if necessary. Your doctor may have you take 1 dose a day or 1 dose every other day.

    Accommodative Esotropia

    Children: Place 1 drop of 0.125 percent solution in both eyes at bedtime for 2 or 3 weeks to diagnose the condition.

    Your doctor may then change the schedule to 0.125 percent every other day or reduce the dose to 0.06 percent every day.

    The maximum dose usually recommended is 0.125 percent solution once daily.

    If the eye drops are slowly withdrawn after a year or two of treatment, and the eye problem returns, your doctor may want you to consider surgery.

  • How should I take Phospholine Iodide?

    Use Phospholine Iodide ophthalmic eye drops exactly as directed by your doctor.

    To prepare eyedrops: 1. Use aseptic technique (techniques which decrease the risk of contaminating the drug or the container which holds the drug); 2. Tear off the aluminum seals, remove and discard rubber plugs from both drug and diluent containers. (A diluent is an ingredient found in medicinal preparation that is used for the dissolution of a drug.); 3. Pour diluent into drug container; 4. Remove dropper assembly from its sterile wrapping. Holding dropper assembly by the screw cap and, without compressing the rubber bulb, insert into drug container and screw down tightly; 5. Shake for several seconds to ensure mixing; 6. Do not cover nor obliterate instructions to patient regarding storage of eyedrops.

    To apply the eye drops: Tilt your head back slightly and pull down on the lower eyelid. Position the dropper above your eye. Look up and away from the dropper. Squeeze out a drop and close your eye. Apply gentle pressure to the inside corner of your eye (near the nose) for about 1 minute to prevent the liquid from draining down the tear duct. If you are using more than 1 drop in the same eye, repeat the process with about 5 minutes between drops. Repeat the process in your other eye if needed.

    Wipe off any excess Phospholine Iodide around your eye with a tissue.

    Wash off any Phospholine Iodide that may get onto your hands.

    Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

  • What should I avoid while taking Phospholine Iodide?

    Use caution when driving, operating machinery, or performing other hazardous activities. Phospholine Iodide may cause your vision to decrease at night. If you experience decreased vision, avoid these activities.

    Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

    If you wear contact lenses, remove them before applying Phospholine Iodide ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Do not use other eye medications during treatment with Phospholine Iodide, except under the direction of your doctor.

    Phospholine Iodide Eye Drops is for use in the eye only. Do not get Phospholine Iodide Eye Drops in your nose or mouth.

  • What are possible food and drug interactions associated with Phospholine Iodide?

    If Phospholine Iodide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Phospholine Iodide with other cholinesterase inhibitors such as edrophonium and pyridostigmine.
  • What are the possible side effects of Phospholine Iodide?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: ache above the eyes, blurred vision, headache, twitching of eyelid, burning, clouded eye lens, cyst formation, decreased pupil size, decreased visual sharpness, excess tears, eye pain, heart irregularities, increased eye pressure, inflamed iris, lid muscle twitching, nearsightedness, red eyes, stinging

  • Can I receive Phospholine Iodide if I am pregnant or breastfeeding?

    The effects of Phospholine Iodide during pregnancy are unknown. Tell your doctor immediately if you are pregnant or plan to become pregnant.

    Phospholine Iodide should not be used by women who are breastfeeding.

  • What should I do if I miss a dose of Phospholine Iodide?

    Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next dose as directed. Do not use a double dose of this medication.
  • How should I store Phospholine Iodide?

    Store in the refrigerator. Do not freeze. Phospholine Iodide Eye Drops may be stored at room temperature for up to 4 weeks. Do not store in the bathroom.