What is PrandiMet?PrandiMet is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes (non-insulin-dependent).
What is the most important information I should know about PrandiMet?PrandiMet can cause a rare but potentially fatal condition called lactic acidosis (a buildup of an acid in the blood). Lactic acidosis is a medical emergency. The most common symptoms of lactic acidosis are feeling very weak or tired, muscle pain, difficulty breathing, sleepiness, and abdominal pain with nausea, vomiting, or diarrhea. If lactic acidosis is suspected, discontinue PrandiMet and seek medical attention immediately.
You have a higher risk of lactic acidosis if you have kidney or liver problems, congestive heart failure, drink a lot of alcohol, have sepsis (a bloodstream infection), or are dehydrated.
PrandiMet may cause severe lowering of blood sugar (hypoglycemia). There is a greater risk of hypoglycemia if you are elderly, debilitated, or malnourished; have adrenal or pituitary gland problems; don't eat enough; or become intoxicated by alcohol.
Loss of blood sugar control may occur when you are exposed to stress such as trauma, fever, infection, or surgery. Insulin may be necessary.
PrandiMet may need to be temporarily stopped if you are undergoing certain contrast (dye) studies or surgery.
Who should not take PrandiMet?You should not take PrandiMet if you have kidney or liver problems, are taking gemfibrozil, have metabolic acidosis (a condition in which there is too much acid in the body), or are allergic to PrandiMet or any of its ingredients.
Do not take PrandiMet if you have type 1 diabetes (insulin-dependent).
What should I tell my doctor before I take the first dose of PrandiMet?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with PrandiMet. Also, talk to your doctor about your complete medical history, especially if you have kidney, liver, or heart problems; drink a lot of alcohol; or if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Your doctor will prescribe the appropriate dose for you based on your previous diabetes medications.
How should I take PrandiMet?PrandiMet should be taken 15 minutes before meals. You can take it from 30 minutes to right before starting to eat. If you skip a meal, you should not take PrandiMet for that meal. PrandiMet can be taken 2-3 times a day.
What should I avoid while taking PrandiMet?Avoid drinking too much alcohol while on PrandiMet, since alcohol increases the chance of getting lactic acidosis.
What are possible food and drug interactions associated with PrandiMet?If PrandiMet is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining PrandiMet with the following: amiloride, digoxin, gemfibrozil, itraconazole, ketaconazole, morphine, procainamide, quinidine, quinine, ranitidine, rifampin, triamterene, trimethoprim, or vancomycin.
What are the possible side effects of PrandiMet?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: low blood sugar, diarrhea, nausea, vomiting, headache, upper respiratory tract infection
Can I receive PrandiMet if I am pregnant or breastfeeding?The effects of PrandiMet during pregnancy are unknown. Prandimet should only be given during pregnancy if clearly needed. Talk to your doctor before taking this drug if you are pregnant or plan to become pregnant.
PrandiMet is not recommended during breastfeeding because it may cause low blood sugar levels in nursing infants.
What should I do if I miss a dose of PrandiMet?Contact your doctor if you miss a dose of PrandiMet.
How should I store PrandiMet?Store at room temperature.
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