Premarin IV

Generic Name: Conjugated Estrogens

  • What is Premarin IV?

    Premarin intravenous (IV) (administered through a vein in your arm) is a medicine that contains a mixture of estrogen hormones. Premarin IV is used to treat certain types of irregular uterine bleeding due to an imbalance of hormones.

  • What is the most important information I should know about Premarin IV?

    Estrogens increase your risk of developing endometrial (inner lining of the uterus) cancer. Tell your doctor immediately if you have any unusual vaginal bleeding while you are using Premarin IV. Vaginal bleeding after menopause may be a warning sign of endometrial cancer.

    Do not use Premarin IV to prevent heart disease, heart attacks, strokes, or dementia. Using Premarin IV may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots. It may also increase your risk of dementia. Talk regularly with your doctor about whether you still need treatment with Premarin IV.

  • Who should not take Premarin IV?

    Do not receive Premarin IV if you have a history of stroke or heart attack in the last year, blood clots, liver problems, unusual vaginal bleeding or other bleeding disorders, or certain cancers, including cancer of the breast or uterus.

    Do not receive Premarin IV if you think you may be pregnant.

    Do not receive Premarin IV if you are allergic to it or any of its ingredients.

  • What should I tell my doctor before I take the first dose of Premarin IV?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Premarin IV. Also, talk to your doctor about your complete medical history, especially if you are pregnant or breastfeeding; have asthma, seizures, migraine headaches, endometriosis (a common gynecological disorder that may result in sores and pain), lupus (disease that affects the immune system); problems with your heart, liver, thyroid, kidneys; or have high blood calcium levels.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is one 25-milligram (mg) injection, intravenously or intramuscularly (injected into the muscle). The dose may be repeated in 6-12 hours if necessary.

  • How should I take Premarin IV?

    Your doctor will administer Premarin IV for you.

  • What should I avoid while taking Premarin IV?

    Do not miss your scheduled follow-up appointments with your doctor.

    Do not drink grapefruit juice since it may increase the side effects of Premarin IV.

  • What are possible food and drug interactions associated with Premarin IV?

    If Premarin IV is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to tell your doctor if you are taking any of the following prior treatment with Premarin IV: antibiotics (such as clarithromycin, erythromycin, or rifampin), antifungals (such as itraconazole or ketoconazole), ritonavir, seizure medications (such as carbamazepine or phenobarbital), or St. John's wort.

  • What are the possible side effects of Premarin IV?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abnormal vaginal bleeding, blood clots, breast lumps or pain, certain types of cancer, chest pain, dizziness, hair loss, headache, heart attack, high blood pressure, liver problems, nausea, pain in your legs or stomach, speech or vision changes, stroke, swelling, vomiting

  • Can I receive Premarin IV if I am pregnant or breastfeeding?

    Premarin IV should not be used during pregnancy and breastfeeding. Premarin IV can cause harm to your unborn or newborn baby if you use it during pregnancy or breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Premarin IV?

    Premarin IV should be given under special circumstances determined by your doctor.

  • How should I store Premarin IV?

    Your doctor will store Premarin IV for you.