Premarin Vaginal

Generic Name: Conjugated Estrogens

  • What is Premarin Vaginal?

    Premarin is a medicine that contains a mixture of estrogens. Premarin cream is used to treat moderate to severe menopausal changes such as dryness, itching, and burning in and around the vagina or painful intercourse caused by menopausal changes.

  • What is the most important information I should know about Premarin Vaginal?

    Estrogens increase your risk of developing endometrial (inner lining of the uterus) cancer. Report any unusual vaginal bleeding immediately to your doctor while you are using Premarin cream. Vaginal bleeding after menopause may be a warning sign of endometrial cancer.

    Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. It may also increase your risk of dementia. Talk regularly with your doctor about whether you still need treatment with Premarin.

    Premarin vaginal cream can weaken latex condoms, diaphragms, and cervical caps.

  • Who should not take Premarin Vaginal?

    Do not take Premarin if you currently have a history of stroke or heart attack in the last year, blood clots, liver problems, unusual vaginal bleeding or other bleeding disorder, or certain cancers, including cancer of the breast or uterus. Do not take Premarin if you think you may be pregnant or are allergic to any of its ingredients.

  • What should I tell my doctor before I take the first dose of Premarin Vaginal?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Premarin. Also, talk to your doctor about your complete medical history, especially if you are breastfeeding, have unusual vaginal bleeding, asthma (wheezing), seizures, migraine headaches, endometriosis (overgrowth of the uterine lining), lupus (disease that affects the immune system), problems with your heart, liver, thyroid, or kidneys, or have high calcium levels in your blood. Also, tell your doctor if you are going to have surgery or will be on bedrest.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Dryness, Itching, or Burning in the Genital Area

    Adults: The recommended dosage is 0.5-2 grams (g) of Premarin cream daily, inserted into the vagina. You may use the cream once daily for 3 weeks and then stop for 1 week.

    Painful Sexual Intercourse

    Adults: The recommended dosage is 0.5 g of Premarin cream inserted into the vagina. You may use the cream twice weekly, or once daily for 3 weeks and then stop for 1 week.

  • How should I take Premarin Vaginal?

    1) Remove cap from tube; 2) Screw nozzle end of applicator onto tube; 3) Gently squeeze tube from the bottom to force sufficient cream into the barrel to provide the prescribed dose. Use the marked stopping points on the applicator as a guide; 4) Unscrew applicator from tube; 5) Lie on back with knees drawn up. Gently insert applicator deeply into the vagina and press plunger downward to its original position.

    To cleanse the applicator, pull the plunger to remove it from the barrel, then wash with mild soap and warm water. Do not boil or use hot water.

  • What should I avoid while taking Premarin Vaginal?

    Do not smoke while using this medication. Smoking can increase your risk of blood clots, stroke, or heart attack caused by conjugated estrogens.

    Avoid taking estrogen along with grapefruit juice.

  • What are possible food and drug interactions associated with Premarin Vaginal?

    No significant interactions have been reported with Premarin cream at this time. However, always tell your doctor about any medicines you take, including over-the-counter drugs, vitamins, and herbal supplements.

  • What are the possible side effects of Premarin Vaginal?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, hair loss, high blood pressure, liver problems, high blood sugar, fluid retention, enlargement of non-cancerous tumors of the uterus (fibroids), vaginal yeast infections

    Warning signs of serious side effects include: breast lumps, unusual vaginal bleeding, dizziness and faintness, changes in speech, severe headaches, chest pain, shortness of breath, pains in your legs, changes in vision, vomiting

    Call your doctor right away if you get any of these warning signs or any other unusual symptom that concerns you.

  • Can I receive Premarin Vaginal if I am pregnant or breastfeeding?

    If you are pregnant or plan to become pregnant, notify your doctor immediately. Premarin and conjugated estrogens should not be taken during pregnancy because of the possibility of harm to your unborn baby.

    If you are breastfeeding, the hormones in Premarin can pass into your breast milk. Your doctor may advise you not to breastfeed while you are taking Premarin.

  • What should I do if I miss a dose of Premarin Vaginal?

    If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your normal schedule. Do not take two doses at once.

  • How should I store Premarin Vaginal?

    Store at room temperature.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

Check out my latest blog post on antidepressants

Premarin Vaginal Related Drugs

Premarin Vaginal Related Conditions