What is Premphase?Premphase is a medicine containing the hormones, estrogen and progestin. It is used to treat moderate to severe symptoms of menopause, such as hot flashes and changes in or around your vagina. Premphase also helps to reduce your chances of getting postmenopausal osteoporosis (thin, weak bones).
What is the most important information I should know about Premphase?Estrogens increase your risk of developing cancer of the uterus. Tell your doctor immediately if you experience any unusual vaginal bleeding while you are taking Premphase.
Do not take Premphase to prevent heart disease, heart attacks, strokes, or dementia. Taking Premphase can increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
Premphase can also increase your risk of dementia, gallbladder disease, ovarian cancer, visual abnormalities, high blood pressure, pancreatitis (inflammation of your pancreas), or thyroid problems. Talk regularly with your doctor about whether you still need treatment with Premphase.
You can lower your chances of serious side effects with Premphase by having a pelvic exam, breast exam, and mammogram (breast x-ray) every year, unless directed by your doctor to have it more often. See your doctor immediately if you get vaginal bleeding while you are taking Premphase. Also, ask your doctor for ways to lower your chances of getting heart disease, especially if you have high blood pressure, high cholesterol, or diabetes, if you are overweight, or if you use tobacco.
Who should not take Premphase?Do not take Premphase if you are allergic to it or any of its ingredients, or if you are pregnant or think you may be pregnant.
Do not take Premphase if you have had your uterus removed, have a history of stroke or heart attack, blood clots, liver problems, unusual vaginal bleeding or other bleeding disorders, or certain cancers, including cancer of your breast or uterus.
What should I tell my doctor before I take the first dose of Premphase?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Premphase. Also, talk to your doctor about your complete medical history, especially if you are pregnant or breastfeeding, or have any unusual vaginal bleeding, asthma, seizures, diabetes, migraine headaches, endometriosis (a common gynecological disorder that may result in sores and pain), lupus (disease that affects the immune system), high blood calcium levels, or problems with your heart, liver, thyroid, or kidneys. Also, tell your doctor if you are going to have surgery or will be on bedrest.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The recommended dose is 1 maroon tablet on days 1-14, followed by 1 light-blue tablet on days 15-28.
How should I take Premphase?Take Premphase exactly as prescribed by your doctor. Take this medication at the same time each day. Talk to your doctor regularly (every 3-6 months) about the dose you are taking and whether you still need treatment with Premphase.
What should I avoid while taking Premphase?Do not smoke while you are taking Premphase. If you smoke, your chances of getting heart disease can increase.
Grapefruit juice can increase your risk of side effects with Premphase. Talk to your doctor before including grapefruit or grapefruit juice in your diet while you are taking Premphase.
What are possible food and drug interactions associated with Premphase?If Premphase is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Premphase with the following: aminoglutethimide, antibiotics (such as clarithromycin, erythromycin, or rifampin), antifungals (such as itraconazole or ketoconazole), grapefruit juice, ritonavir, seizure medications (such as carbamazepine or phenobarbital), or St. John's wort.
What are the possible side effects of Premphase?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: abdominal pain, breast pain, fluid retention, hair loss, headache, irregular vaginal bleeding or spotting, nausea, vomiting
If you experience symptoms of breast lumps, changes in your speech, changes in your vision, chest pain, dizziness and faintness, pain in your legs, severe headaches, shortness of breath, unusual vaginal bleeding, vomiting, or yellowing of your skin or whites of your eyes, contact your doctor immediately.
Can I receive Premphase if I am pregnant or breastfeeding?Do not take Premphase if you are pregnant or breastfeeding. The hormones in Premphase can be found in your breast milk if you take it while you are breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Premphase?If you miss a dose of Premphase, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store Premphase?Store at room temperature.