Generic Name: Conjugated Estrogens

  • What is Prempro?

    Prempro is a medicine containing the hormones, estrogen and progestin. It is used to treat moderate to severe symptoms of menopause, such as hot flashes and changes in or around your vagina. Prempro also helps to reduce your chances of getting postmenopausal osteoporosis (thin, weak bones).

  • What is the most important information I should know about Prempro?

    Estrogens increase your risk of developing cancer of the uterus. Tell your doctor immediately if you experience any unusual vaginal bleeding while you are taking Prempro.

    Do not take Prempro to prevent heart disease, heart attacks, strokes, or dementia. Taking Prempro can increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

    Prempro can also increase your risk of dementia, gallbladder disease, ovarian cancer, visual abnormalities, high blood pressure, pancreatitis (inflammation of the pancreas), or thyroid problems. Talk regularly with your doctor about whether you still need treatment with Prempro.

    You can lower your chances of serious side effects with Prempro by having a pelvic exam, breast exam, and mammogram (breast x-ray) every year, unless directed by your doctor to have it more often. See your doctor immediately if you get vaginal bleeding while you are taking Prempro. Also, ask your doctor for ways to lower your chances of getting heart disease, especially if you have high blood pressure, high cholesterol, or diabetes, if you are overweight, or if you use tobacco.

  • Who should not take Prempro?

    Do not take Prempro if you are allergic to it or any of its ingredients, or if you are pregnant or think you may be pregnant.

    Do not take Prempro if you have had your uterus removed, have a history of stroke or heart attack, blood clots, liver problems, unusual vaginal bleeding or other bleeding disorders, or certain cancers, including cancer of your breast or uterus.

  • What should I tell my doctor before I take the first dose of Prempro?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Prempro. Also, talk to your doctor about your complete medical history, especially if you are pregnant or breastfeeding, or have any unusual vaginal bleeding, asthma, seizures, diabetes, migraine headaches, endometriosis (a common gynecological disorder that may result in sores and pain), lupus (disease that affects the immune system), high blood calcium levels, or problems with your heart, liver, thyroid, or kidneys. Also, tell your doctor if you are going to have surgery or will be on bedrest.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is 1 tablet once a day.

  • How should I take Prempro?

    Take Prempro exactly as prescribed by your doctor. Take this medication at the same time each day. Talk to your doctor regularly (every 3-6 months) about the dose you are taking and whether you still need treatment with Prempro.

  • What should I avoid while taking Prempro?

    Do not smoke while you are taking Prempro. If you smoke, your chances of getting heart disease can increase.

    Grapefruit juice can increase your risk of side effects with Prempro. Talk to your doctor before including grapefruit or grapefruit juice in your diet while you are taking Prempro.

  • What are possible food and drug interactions associated with Prempro?

    If Prempro is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Prempro with the following: aminoglutethimide, antibiotics (such as clarithromycin, erythromycin, or rifampin), antifungals (such as itraconazole or ketoconazole), grapefruit juice, ritonavir, seizure medications (such as carbamazepine or phenobarbital), or St. John's wort.

  • What are the possible side effects of Prempro?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abdominal pain, breast pain, fluid retention, hair loss, headache, irregular vaginal bleeding or spotting, nausea, vomiting

    If you experience symptoms of breast lumps, changes in your speech, changes in your vision, chest pain, dizziness and faintness, pain in your legs, severe headaches, shortness of breath, unusual vaginal bleeding, vomiting, or yellowing of your skin or whites of your eyes, contact your doctor immediately.

  • Can I receive Prempro if I am pregnant or breastfeeding?

    Do not take Prempro if you are pregnant or breastfeeding. The hormones in Prempro can be found in your breast milk if you take it while you are breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Prempro?

    If you miss a dose of Prempro, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Prempro?

    Store at room temperature.