Prinzide

Generic Name: Lisinopril

  • What is this medication and its most common uses?

    Prinzide is a medicine used to treat high blood pressure. Prinzide contains two medicines that work in two different ways to reduce your blood pressure: lisinopril and hydrochlorothiazide.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Lisinopril works by blocking a chemical in your body that causes blood vessels to narrow. By blocking this chemical, lisinopril relaxes and widens your blood vessels, allowing your blood to flow through with less resistance. Hydrochlorothiazide is a water pill and works by eliminating extra fluid and sodium (salt) from your body. Together, they help lower your blood pressure.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: By lowering your blood pressure, Prinzide may lower your risk of a stroke or a heart attack.

    When: Prinzide may start lowering your blood pressure within 2 weeks. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Prinzide can harm your unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking Prinzide.

    More common side effects may include: dizziness, headache, cough, fatigue, a sudden fall in your blood pressure.

    Less common side effects may include:

    Serious allergic reaction with symptoms such as extreme swelling of your face, lips, tongue, throat, or gut (causing severe abdominal [stomach area] pain). You may have an increased risk of experiencing these symptoms if you have a history of angioedema (a condition involving swelling of the face, extremities, eyes, lips, and tongue) or if you are African American.

    Low blood pressure with symptoms such as lightheadedness, especially during the first few days of taking Prinzide. Dehydration, excessive sweating, diarrhea, or vomiting can lead to an excessive fall in your blood pressure, which can cause lightheadedness and possible fainting.

    Kidney problems with symptoms such as swelling in your feet, ankles, or hands; or unexplained weight gain.

    Low blood neutrophil (type of blood cells that fight infections) levels with symptoms of an infection (such as sore throat or fever).

    Temporary nearsightedness (trouble seeing objects farther away) or glaucoma (high pressure in the eye) with symptoms such as changes in your vision or eye pain that may occur within hours to weeks of starting Prinzide.

    Changes in electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, dizziness or fainting, low or no urine output, fast heartbeat, or nausea and vomiting.

  • Who should not take this medication?

    Do not take Prinzide if you are allergic to it, any of its ingredients, other sulfonamide medications (such as sulfamethoxazole), or if you have a history of angioedema related to previous treatment with similar medicines.

    Do not take Prinzide if you are unable to produce urine.

    If you are diabetic, do not take Prinzide in combination with aliskiren.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Prinzide. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; asthma; a disease that affects your immune system (such as lupus or scleroderma); gout; high cholesterol levels; kidney, liver, or heart problems; plan to undergo surgery or receive anesthesia; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The recommended dose is 10/12.5 (10 milligrams [mg] of lisinopril and 12.5 mg of hydrochlorothiazide) or 20/12.5 (20 milligrams of lisinopril and 12.5 mg of hydrochlorothiazide) once a day. Your healthcare provider will prescribe the appropriate dose for you based on your previous blood pressure medication, and may increase your dose as needed, until the desired effect is achieved.

  • How should I take this medication?

    Take Prinzide exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Prinzide without first talking to your healthcare provider.

  • What should I avoid while taking this medication?

    Do not become pregnant while taking this medication.

    Do not become dehydrated. Drink plenty of fluids while you are taking Prinzide.

    Do not take potassium supplements or salt substitutes that contain potassium without first talking to your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If Prinzide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Prinzide with the following: alcohol, aliskiren, barbiturates (such as phenobarbital), blood pressure/heart medications called angiotensin receptor blockers (ARBs) (such as losartan or valsartan), cholestyramine, colestipol, diabetes medicines (such as insulin), injectable gold (sodium aurothiomalate), lithium, muscle relaxants (such as tubocurarine), narcotic painkillers (such as hydrocodone or oxycodone), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), norepinephrine, potassium supplements, salt substitutes that contain potassium, steroids (such as prednisone), or water pills (such as amiloride, spironolactone, or triamterene).

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take Prinzide if you are pregnant or breastfeeding. Prinzide can harm your unborn baby. Prinzide can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Prinzide, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from excess light and humidity.