Generic Name: Progesterone

  • What is Prochieve?

    Prochieve is a vaginal gel used to treat progesterone deficiency in women undergoing infertility treatment. It is also prescribed to restore menstruation in women whose menstrual periods have stopped.

  • What is the most important information I should know about Prochieve?

    Progesterone therapy can cause blood clots in susceptible individuals. Call your doctor immediately if you develop any of the following: pain in the calves or chest, shortness of breath, coughing up blood, severe headache, severe vomiting, dizziness, faintness, changes in vision or speech, and weakness or numbness in an arm or leg.

    If you are undergoing infertility treatment, it is very important that you strictly adhere to the Prochieve schedule your doctor has planned for you. Administering the dose at the wrong time or forgetting to take a dose may jeopardize your chances of getting pregnant and maintaining a pregnancy. Before starting progesterone therapy, your doctor will do a complete gynecological exam, including a Pap smear, to rule out cancer. Be sure to tell the doctor about any unusual vaginal bleeding before using Prochieve.

  • Who should not take Prochieve?

    Do not take Prochieve if you have a known sensitivity or allergy to Prochieve (progesterone) or any of its other components. Do not take Prochieve if you have liver disease, known or suspected cancer of the breast or genitals, a history of blood clots, or unusual vaginal bleeding that has not been evaluated by a doctor.

    If you've had a miscarriage and your doctor suspects some tissue remains in the uterus, do not use Prochieve.

  • What should I tell my doctor before I take the first dose of Prochieve?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Prochieve. Also, talk to your doctor about your complete medical history, especially if you have high blood pressure, heart disease, congestive heart failure, migraines, asthma, kidney disease, liver disease, seizures or epilepsy, a history of depression, or diabetes.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.


    Adults: Prochieve 8% is administered vaginally at a dose of 90 milligrams (mg) once daily in women who require progesterone supplementation. Prochieve 8% is administered vaginally at a dose of 90 mg twice daily in women with partial or complete ovarian failure who require progesterone replacement. If pregnancy occurs, treatment may be continued until the placenta has enough progesterone to support itself, up to 10-12 weeks.

    To Restore Menstrual Periods

    Adults: The usual dose is one application of Prochieve 4% gel every other day as directed by your doctor, up to a total of 6 doses. One application of the 4% gel delivers 45 mg of progesterone. If needed, the doctor may increase your dose by switching you to the 8% gel.

  • How should I take Prochieve?

    Remove the applicator from the sealed wrapper (do not remove the twist-off tab at this point). Hold the applicator by the thick end and shake several times as you would a thermometer to move the contents to the thin end. Hold the applicator by the flat section of the thick end. Twist off and throw away the tab. Do not squeeze the thick end while twisting the tab. Gently insert the thin end of the applicator into the vagina. Squeeze the thick end of the applicator to deposit the gel. Remove the applicator and throw it away.

    For altitudes above 2,500 feet, follow label instructions.

    Note that if your doctor prescribes the 8% gel, you cannot substitute two tubes of the 4% gel, as the proper amount of drug will not be absorbed.

  • What should I avoid while taking Prochieve?

    Do not use other vaginal products while you are using progesterone vaginally unless your doctor has directed you to do so.

  • What are possible food and drug interactions associated with Prochieve?

    There are no known drug interactions with Prochieve. However, other vaginal medications should not be used at the same time. Tell your doctor if you use any other vaginal medications and ask about the best time to administer each one.

  • What are the possible side effects of Prochieve?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abdominal pain, acne, allergy, back pain, bloating, breast pain, cramps, depression, dizziness, fatigue, flulike symptoms, frequent urination, gas, gastrointestinal discomfort, genital itching, headache, hot flushes, increased appetite, increased sweating, infections, insomnia, leg pain, migraine, mood swings, muscle pain, nausea, nervousness, pain, painful menstruation, rash, sleep problems, sleepiness, thirst, tremor, upper respiratory tract infection, vaginal discharge, yeast infection

  • Can I receive Prochieve if I am pregnant or breastfeeding?

    Prochieve is used in women who are undergoing infertility treatment. Rare cases of birth defects have been reported in women who used Prochieve during early pregnancy, although a definite cause/effect relationship has not been established. Tell your doctor if you become pregnant. Because progesterone is excreted in breast milk, be sure to tell the doctor if you're breastfeeding.

  • What should I do if I miss a dose of Prochieve?

    Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and take the next one as scheduled.

  • How should I store Prochieve?

    Store Prochieve at room temperature.

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I'm Kristen Dore, PharmD. Welcome to PDR Health!

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