Promethazine with codeine

Generic Name: Codeine

  • What is Promethazine with codeine?

    Promethazine, when combined with codeine, is used to relieve cough and other symptoms of allergies and the common cold.

  • What is the most important information I should know about Promethazine with codeine?

    This product should not be used in children <6 years old. Serious and sometimes fatal side effects (difficult or slowed breathing, drowsiness leading to coma) have occurred when promethazine has been used in children.

    Neuroleptic malignant syndrome (a life-threatening brain disorder) is a possibly fatal syndrome that can be caused by promethazine. Symptoms may include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact your doctor at once if you have any of these symptoms.

    Promethazine should be used with caution in patients who have seizures or are on other medications that may make you more prone to having a seizure.

    Promethazine should be avoided or used with extreme caution in patients with poor breathing function due to the risk of serious side effects.

    If you experience any involuntary muscle movements, report them to your doctor.

    It is possible to develop psychological and physical dependence on codeine. Although the likelihood of this is quite low with oral codeine, be cautious if you have a history of drug abuse or dependence.

    Never take more cough syrup than has been prescribed. If your cough does not seem better within 5 days, check back with your doctor.

    This medication might make you dizzy when standing or sitting up quickly. Get up slowly from a reclining position to prevent this.

  • Who should not take Promethazine with codeine?

    This product should not be used in pediatric patients <6 years old.

    Promethazine is not to be used in patients who have severe central nervous system depression.

    Do not use this medication if you have a known hypersensitivity or allergic reaction to phenothiazines or codeine

  • What should I tell my doctor before I take the first dose of Promethazine with codeine?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with promethazine. Also, talk to your doctor about your complete medical history, especially if you have nervous system problems, bone marrow depression, heart problems, low blood pressure, blood disease, glaucoma (increased pressure in the eye), liver problems, prostate problems, Parkinson's disease, seizures, or if you consume large amounts of alcohol.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults and adolescents ≥12 years: The usual dosage is 1 teaspoon (5 milliliters [mL]) every 4-6 hours, not to exceed 6 teaspoons, or 30 mL, in 24 hours.

    Children 6-12 years: The usual dose is 1/2 teaspoon (2.5 mL) every 4-6 hours, not to exceed 30 mL in 24 hours.

  • How should I take Promethazine with codeine?

    Take with or without food, exactly as prescribed by your doctor.

    Use an appropriate measuring device; a household teaspoon may not be an accurate dosage measurement.

  • What should I avoid while taking Promethazine with codeine?

    Do not drive or perform other possibly unsafe tasks until you know how you react to this medication; this drug may cause dizziness, drowsiness, or blurred vision.

    Do not drink alcohol or use medicines that may cause drowsiness (such as sleep aids and muscle relaxers) while you are using promethazine with codeine; it may add to their effects.

    Avoid the sun, sunlamps, or tanning booths until you know how you react to promethazine. Promethazine may cause you to become sunburned more easily. Use sunscreen or wear protective clothing if you must be outside for more than a short time.

  • What are possible food and drug interactions associated with Promethazine with codeine?

    If this product is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining it with the following: alcohol, angiotensin-converting enzyme (ACE) inhibitors such as enalapril, antidepressants, astemizole, bromocriptine, cisapride, epinephrine, haloperidol, levodopa, lithium, meperidine, methyldopa, monoamine oxidase inhibitors (MAOIs) such as phenelzine, naltrexone, narcotic pain relievers, pergolide, polypeptide antibiotics such as actinomycin, terfenadine, thiopental, tramadol, trazodone, sedatives, or tranquilizers.

  • What are the possible side effects of Promethazine with codeine?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: constipation, dizziness, drowsiness, dry mouth, increased or decreased blood pressure, nausea, occasional blurred vision, rash, sleepiness, vomiting, sensitivity to light, uncontrolled muscle movements, yellowing of the skin or eyes, severe allergic reactions (rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue)

  • Can I receive Promethazine with codeine if I am pregnant or breastfeeding?

    The effects of promethazine with codeine during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Promethazine with codeine?

    If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at once.

  • How should I store Promethazine with codeine?

    Store at room temperature.

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