Generic Name: Progesterone

  • What is Prometrium?

    Prometrium is a female hormone prescribed for postmenopausal women who are taking estrogen; it prevents a buildup of the uterine lining and abnormal bleeding. Prometrium also may be prescribed to restore menstruation if your menstrual periods have stopped unexpectedly.

  • What is the most important information I should know about Prometrium?

    Prometrium should not be used to prevent heart disease, stroke, or dementia. Prometrium increases the risk of blood clots, which can lead to breathing problems, vision problems, or stroke. If you experience any symptoms that might suggest the onset of a clot-related disorder--pain with swelling, warmth, and redness in a leg vein, coughing or shortness of breath, loss of vision or double vision, migraine, or weakness or numbness in an arm or leg--stop taking Prometrium and see your doctor immediately. Prometrium may also increase risk of developing breast cancer or dementia.

    Before you start taking Prometrium, your doctor will give you a complete physical exam, including examination of your breasts and pelvis. You also should have a Pap test (cervical smear). Tell your doctor if you experience any irregular vaginal bleeding while taking Prometrium.

  • Who should not take Prometrium?

    Do not take Prometrium if you have ever had an allergic reaction to it. Because Prometrium contains peanut oil, avoid Prometrium if you are allergic to peanuts.

    Do not take Prometrium if you are pregnant or have had an incomplete miscarriage, if you have ever had a blood clotting disorder or a stroke, or if you have breast or a genital cancer, unexplained vaginal bleeding, or severe liver disease.

  • What should I tell my doctor before I take the first dose of Prometrium?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Prometrium. Also, talk to your doctor about your complete medical history, especially if you have high blood pressure, heart disease, congestive heart failure, migraines, asthma, kidney disease, seizures, an abnormal PAP smear, or a history of depression or diabetes.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Prevent Abnormal Buildup of the Uterine Lining

    Adults: For women taking daily conjugated estrogen tablets, the usual dosage of Prometrium is 200 milligrams (mg) taken at bedtime for 12 days sequentially per 28-day cycle.

    To Restore Menstrual Periods

    Adults: The usual dose is 400 mg taken at bedtime for 10 days.

  • How should I take Prometrium?

    Take Prometrium as directed by your doctor. Take the capsules with a glass of water while in a standing position.

  • What should I avoid while taking Prometrium?

    Prometrium may make you dizzy or drowsy. Do not drive or operate machinery until you know how Prometrium affects you. If you experience extreme drowsiness or dizziness, your doctor may tell you to only take Prometrium at bedtime.

  • What are possible food and drug interactions associated with Prometrium?

    If Prometrium is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Prometrium with antifungal medication such as ketoconazole or estrogen-containing medicines, such as birth control pills.

  • What are the possible side effects of Prometrium?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abdominal cramping, back pain, bloating, breast tenderness or pain, chest pain, constipation, coughing, depression, diarrhea, dizziness, emotional instability, fatigue, hair loss, headache, hot flashes, irritability, joint pain, muscle pain, nausea, night sweats, swelling of hands and feet, upper respiratory infection, urinary problems, vaginal discharge, bleeding or spotting, vaginal dryness, viral infection, vomiting, yeast infection

  • Can I receive Prometrium if I am pregnant or breastfeeding?

    Because the possibility of harm to a developing baby, Prometrium should not be taken during pregnancy. Prometrium appears in breast milk. It is recommended for breastfeeding mothers only if the benefits outweigh the risks.

  • What should I do if I miss a dose of Prometrium?

    Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take two doses at once.

  • How should I store Prometrium?

    Store at room temperature.

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I'm Kristen Dore, PharmD. Welcome to PDR Health!

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