Generic Name: Dornase Alfa

  • What is Pulmozyme?

    Pulmozyme is used in addition to standard therapies to improve lung function in patients with cystic fibrosis. Pulmozyme may reduce the risk of respiratory tract infections requiring injectable antibiotics in some patients.

  • What is the most important information I should know about Pulmozyme?

    Pulmozyme should be refrigerated and kept refrigerated during transport and should not be exposed to room temperatures for a total time of 24 hours. Protect from strong light. Throw out any solution that is cloudy or discolored. Pulmozyme contains no preservative and, once opened, the entire contents of the ampule must be used or thrown away.

    Receive training from your healthcare provider and refer to the pamphlet that accompanies the nebulizer and compressor system for instructions for proper use and maintenance.

    Pulmozyme should be used in conjunction with standard therapies for cystic fibrosis.

  • Who should not take Pulmozyme?

    Do not take Pulmozyme if you are allergic to dornase alfa, Chinese Hamster Ovary cell products, or any component of the product.

    There is limited experience with the use of Pulmozyme in patients younger than 5 years of age. Consider use only if potential benefit in lung function or in risk of respiratory tract infection.

  • What should I tell my doctor before I take the first dose of Pulmozyme?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Pulmozyme. Also, talk to your doctor about your complete medical history, especially if you have respiratory tract infections, pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults and Children: The usual dosage of Pulmozyme is one 2.5 milligram (mg) single-use ampule inhaled once daily using a recommended nebulizer. Some patients may benefit from taking it twice daily.

  • How should I take Pulmozyme?

    Before taking or administering Pulmozyme, it is important to receive training from your cystic fibrosis healthcare team. You will need the following items for Pulmozyme administration: one ampule of Pulmozyme, one nebulizer approved for use with Pulmozyme, tubing and other components that come with nebulizer, a mouthpiece (or for children younger than 5 years, a face mask), a compressor compatible with your nebulizer.

    Your healthcare provider will teach you how to take or administer Pulmozyme.

    Pulmozyme should not be diluted or mixed with other drugs in the nebulizer.

  • What should I avoid while taking Pulmozyme?

    Avoid having Pulmozyme at room temperature for a total time of 24 hours.

    Avoid missing doses of Pulmozyme. Even when you feel well, your disease is still present. It is important to take Pulmozyme everyday, whether you have symptoms or not.

  • What are possible food and drug interactions associated with Pulmozyme?

    No significant interactions have been reported with Pulmozyme at this time. However, always tell your doctor about any medicines you take, including over-the-counter drugs and supplements and herbal medicines.

  • What are the possible side effects of Pulmozyme?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: voice alteration, sore throat, rash, laryngitis, chest pain, pink eye, inflammation of the nose, fever, upset stomach, trouble breathing

  • Can I receive Pulmozyme if I am pregnant or breastfeeding?

    The effects of Pulmozyme in pregnancy and breastfeeding are unknown. Talk to your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Pulmozyme?

    If you missed a dose of Pulmozyme, take the dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at the same time. If you are unsure, ask your doctor or pharmacist for advice.

  • How should I store Pulmozyme?

    Pulmozyme must be stored in the refrigerator and protected from strong light. Keep refrigerated during transport and do not expose to room temperatures for a total time of 24 hours. Store unused ampules in their protective foil pouch under refrigeration.

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I'm Beth Isaac, PharmD. Welcome to PDR Health!

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