What is Rapamune?Rapamune is a medicine used to prevent transplant rejection in people who have received a kidney transplant. Rapamune is used with other medications called cyclosporine and corticosteroids (medications that help fight inflammation). Rapamune is available in an oral solution and tablets.
What is the most important information I should know about Rapamune?Rapamune can cause serious side effects, such as an increased risk of getting infections caused by bacteria, viruses, or fungi. Tell your doctor immediately if you experience fever or chills while you are taking Rapamune. Also, Rapamune can cause an increased risk of getting cancers, especially skin cancer. Talk with your doctor about your risk.
Who should not take Rapamune?Do not take Rapamune if you are allergic to it or any of its ingredients.
Do not take Rapamune if you have had a liver or lung transplant, as it can cause serious complications.
What should I tell my doctor before I take the first dose of Rapamune?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Rapamune. Also, talk to your doctor about your complete medical history, especially if you have liver problems, skin cancer or a family history of skin cancer, high cholesterol, or plan to receive any vaccines.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults and children ≥13 years: Your doctor will prescribe the appropriate dose for you based on your condition and body weight.
How should I take Rapamune?Take Rapamune exactly as prescribed by your doctor. Take it by mouth once a day. You should take this medication the same way each day, with or without food. Do not crush, chew, or split Rapamune tablets. If you take cyclosporine with Rapamune, you should take those medications about 4 hours apart.
Do not change your dose unless your doctor tells you to. Your doctor will check the Rapamune levels in your blood and will change your dose depending on the levels.
When a bottle of Rapamune oral solution is opened, it should be used within one month. Rapamune oral solution can develop a slight haze when it is refrigerated. If this happens, bring the solution to room temperature and gently shake the bottle until the haze disappears. If you get Rapamune oral solution on your skin or in your eyes, rinse thoroughly with water.
What should I avoid while taking Rapamune?Do not receive live vaccines (such as measles, mumps, rubella, oral polio, BCG, or varicella) while you are taking Rapamune. This medication can decrease the effects of certain vaccines.
Do not excessively expose your skin to the sun or UV light because of the increased risk for skin cancer with Rapamune. Cover your skin with protective clothing and use a sunscreen.
Do not drink grapefruit juice while you are taking Rapamune.
What are possible food and drug interactions associated with Rapamune?If Rapamune is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Rapamune may interact with numerous medications. Therefore, it is very important that you tell your doctor about any other medications you are taking.
What are the possible side effects of Rapamune?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: allergic reactions, blood clotting problems, breathing problems, diarrhea, edema (swelling), fever, high blood pressure, increased blood cholesterol levels, increased risk for cancer, increased risk for infections, kidney or lung problems, low red blood cell counts, pain, poor wound healing
Can I receive Rapamune if I am pregnant or breastfeeding?The effects of Rapamune during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Rapamune?If you miss a dose of Rapamune, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store Rapamune?Rapamune tablet: Store at room temperature.
Rapamune oral solution: Store in the refrigerator.